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The GPR139 agonist TAK-041 produces time-dependent alterations to cerebral blood flow and reward system function in patients with schizophrenia: a randomised placebo-controlled trial.

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Title: The GPR139 agonist TAK-041 produces time-dependent alterations to cerebral blood flow and reward system function in patients with schizophrenia: a randomised placebo-controlled trial.
Authors: Hawkins PCT; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK., Schwarz AJ; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA., Stone JM; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK.; Brighton and Sussex Medical School, University of Sussex, Brighton, UK., Pepper F; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK., Gilleen J; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK., Gijsen S; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK., Mazibuko N; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK., Arkilo D; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA., Yin W; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA., Wu J; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA., Khudyakov P; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA., Behrje R; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA., Rosen L; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA., Posener J; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA., Mehta MA; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK. Mitul.Mehta@kcl.ac.uk., Laurenza A; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA. antonio.laurenza@takeda.com.
Source: Psychopharmacology [Psychopharmacology (Berl)] 2026 Apr; Vol. 243 (4), pp. 819-829. Date of Electronic Publication: 2025 Aug 16.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The GPR139 agonist TAK-041 produces time-dependent alterations to cerebral blood flow and reward system function in patients with schizophrenia: a randomised placebo-controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Hawkins+PCT%22">Hawkins PCT</searchLink>; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK.<br /><searchLink fieldCode="AU" term="%22Schwarz+AJ%22">Schwarz AJ</searchLink>; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Stone+JM%22">Stone JM</searchLink>; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK.; Brighton and Sussex Medical School, University of Sussex, Brighton, UK.<br /><searchLink fieldCode="AU" term="%22Pepper+F%22">Pepper F</searchLink>; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK.<br /><searchLink fieldCode="AU" term="%22Gilleen+J%22">Gilleen J</searchLink>; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK.<br /><searchLink fieldCode="AU" term="%22Gijsen+S%22">Gijsen S</searchLink>; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK.<br /><searchLink fieldCode="AU" term="%22Mazibuko+N%22">Mazibuko N</searchLink>; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK.<br /><searchLink fieldCode="AU" term="%22Arkilo+D%22">Arkilo D</searchLink>; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Yin+W%22">Yin W</searchLink>; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Khudyakov+P%22">Khudyakov P</searchLink>; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Behrje+R%22">Behrje R</searchLink>; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+L%22">Rosen L</searchLink>; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Posener+J%22">Posener J</searchLink>; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+MA%22">Mehta MA</searchLink>; Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, SE5 8AF, UK. Mitul.Mehta@kcl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Laurenza+A%22">Laurenza A</searchLink>; Takeda Pharmaceuticals Ltd, Cambridge, MA, 02139, USA. antonio.laurenza@takeda.com.
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  Data: <searchLink fieldCode="JN" term="%227608025%22">Psychopharmacology</searchLink> [Psychopharmacology (Berl)] 2026 Apr; Vol. 243 (4), pp. 819-829. <i>Date of Electronic Publication: </i>2025 Aug 16.
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