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Functionally deficient UBOX5 variants and primary angle-closure glaucoma.

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Title: Functionally deficient UBOX5 variants and primary angle-closure glaucoma.
Authors: Li Z; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore., Chng WL; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.; Duke-NUS Medical School, National University of, Singapore, Singapore., Liu Z; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.; Duke-NUS Medical School, National University of, Singapore, Singapore., Do T; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Nakano M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Chen LJ; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Loo Y; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Chan ASY; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Topouzis F; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Nongpiur ME; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Ozaki M; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ozaki Eye Hospital, Hyuga, and Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Nakano S; Department of Ophthalmology, Oita University Faculty of Medicine, Yufu, Japan., Kubota T; Department of Ophthalmology, Oita University Faculty of Medicine, Yufu, Japan., Perera SA; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Husain R; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Wong TTL; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Cheng CY; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Ho CL; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Abu-Amero K; Department of Research, King Khaled Eye Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Wong HT; Dept of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore, Singapore., Melo MB; Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas, Campinas, SP, Brazil., Hien NDTN; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Van Trinh N; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Huong NTT; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Azhany Y; Department of Ophthalmology and Visual Science, School of Medical Sciences, Health campus, Universiti Sains Malaysia and Hospital Pakar Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Perez-Grossmann R; Instituto de Glaucoma y Catarata, Lima, Perú., Chan PP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Stuart KV; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK., Biradar MI; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK., Szabo A; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK., Anastasopoulos E; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Giannoulis DA; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Ntonti P; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Papakonstantinou E; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Lambropoulos A; Laboratory of Medical Biology - Genetics, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Chatzikyriakidou A; Laboratory of Medical Biology - Genetics, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Kilintzis V; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Ayub H; Department of Biological and Health Sciences, Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Mang, Haripur, KPK, Pakistan., Micheal S; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands., Aung YY; Mandalay Eye department, Mandalay Eye ENT hospital, University of Medicine Mandalay, Mandalay, Myanmar., Leuenberger EU; Asian Eye Institute, Manila, Philippines.; University of the East Ramon Magsaysay College of Medicine, Manila, Philippines., Fea A; Dipartimento di Scienze Chirurgiche - Universita' di Torino, Turin, Italy., Mon NN; Duke-NUS Medical School, National University of, Singapore, Singapore., Anajao A; Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore, Singapore., Bi X; Duke-NUS Medical School, National University of, Singapore, Singapore.; Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore, Singapore., Kok YJ; Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore, Singapore., Chong RS; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Boey PY; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Tan DZJ; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore., Sin WWL; Duke-NUS Medical School, National University of, Singapore, Singapore., Chowbay B; National Cancer Centre of, Singapore, Singapore., Khaing CC; Department of Ophthalmology, No(1) Defence Services General Hospital, Yangon, Myanmar., Aung YM; Myanmar Eye Centre, Grand Hantha International Hospital, Yangon, Myanmar.; University Hospitals Coventry and Warwickshire Trust, Coventry, United Kingdom., Reyes RD; Department of Ophthalmology/Glaucoma Section, Asian Hospital & Medical Center, Muntinlupa City, Philippines., Panagiotou ES; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Mikropoulos DG; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Voudouragkaki IC; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Panos GD; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Division of Ophthalmology and Visual Sciences, School of Medicine, University of Nottingham, Nottingham, UK., Xie Z; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore., Chen XY; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore., Lim YT; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore., Meah WY; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore., Lee YS; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Ho CEH; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Yeo PMX; Duke-NUS Medical School, National University of, Singapore, Singapore., Ikeda Y; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Tokuda Y; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Tanaka M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Omi N; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ueno M; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., de Vasconcellos JPC; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil., Costa VP; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil., Abe RY; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil., de Souza BB; Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas, Campinas, SP, Brazil., Fong GB; Instituto de Ciencias Medicas, Lima, Perú., Castro VV; Hospital Nacional Arzobispo Loayza, Lima, Perú., Fujita R; Centro de Genetica y Biologia Molecular, Universidad de San Martin de Porres, Lima, Perú., Guevara-Fujita ML; Centro de Genetica y Biologia Molecular, Universidad de San Martin de Porres, Lima, Perú., Akhtar F; Department of Glaucoma, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan., Ali M; Department of Glaucoma, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan., Catacutan MAT; Asian Eye Institute, Manila, Philippines., Felarca IR; Asian Eye Institute, Manila, Philippines., Liao CS; Asian Eye Institute, Manila, Philippines., Lavia C; Dipartimento di Scienze Chirurgiche - Universita' di Torino, Turin, Italy., Than HM; Department of Ophthalmology, North Okkalarpa General Hospital, Yangon, Myanmar., Oo KT; Myanmar Eye Centre, Grand Hantha International Hospital, Yangon, Myanmar., Soe-Kyaw PP; Myanmar Eye Centre, Grand Hantha International Hospital, Yangon, Myanmar., Frezzotti P; Surgery Department, Section of Ophthalmology, University of Siena, Siena, Italy., Pasutto F; Humangenetisches Institut, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Kussmaulallee 4, 91054, Erlangen, Germany., Quino R; Department of Ophthalmology/Glaucoma Section, Asian Hospital & Medical Center, Muntinlupa City, Philippines.; University of the Philippines- College of Medicine, Manila, Philippines., Minn-Din Z; Myanmar Eye Centre, Grand Hantha International Hospital, Yangon, Myanmar., Oo NL; Department of Ophthalmology, No(1) Defence Services General Hospital, Yangon, Myanmar., Dallorto L; Dipartimento di Scienze Chirurgiche - Universita' di Torino, Turin, Italy., Set SH; Mandalay Eye department, Mandalay Eye ENT hospital, University of Medicine Mandalay, Mandalay, Myanmar., Doan VH; Hue University of Medicine and Pharmacy, Danang City, Vietnam., Qamar R; Science and Environment Sector, ICESCO, Rabat, Morocco.; Pakistan Academy of Sciences, Islamabad, Pakistan., Neto JM; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil., Al-Obeidan S; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Tham CC; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Mori K; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Sotozono C; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kinoshita S; Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Konstas AG; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Liza-Sharmini AT; Department of Ophthalmology and Visual Science, School of Medical Sciences, Health campus, Universiti Sains Malaysia and Hospital Pakar Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Zenteno JC; Rare Disease Diagnostic Unit/Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico.; Genetics Department, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico., Do NH; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam., Foster PJ; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK., Tashiro K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Khawaja AP; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK., Aung T; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Wang Z; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore. zhenxun.wang@duke-nus.edu.sg.; Duke-NUS Medical School, National University of, Singapore, Singapore. zhenxun.wang@duke-nus.edu.sg.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. zhenxun.wang@duke-nus.edu.sg., Khor CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore. khorcc@a-star.edu.sg.
Source: Nature communications [Nat Commun] 2025 Aug 15; Vol. 16 (1), pp. 7620. Date of Electronic Publication: 2025 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Group: Ti
  Data: Functionally deficient UBOX5 variants and primary angle-closure glaucoma.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chng+WL%22">Chng WL</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.; Duke-NUS Medical School, National University of, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.; Duke-NUS Medical School, National University of, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Do+T%22">Do T</searchLink>; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Nakano+M%22">Nakano M</searchLink>; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Chen+LJ%22">Chen LJ</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Loo+Y%22">Loo Y</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+ASY%22">Chan ASY</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Topouzis+F%22">Topouzis F</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Nongpiur+ME%22">Nongpiur ME</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ozaki+M%22">Ozaki M</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ozaki Eye Hospital, Hyuga, and Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.<br /><searchLink fieldCode="AU" term="%22Nakano+S%22">Nakano S</searchLink>; Department of Ophthalmology, Oita University Faculty of Medicine, Yufu, Japan.<br /><searchLink fieldCode="AU" term="%22Kubota+T%22">Kubota T</searchLink>; Department of Ophthalmology, Oita University Faculty of Medicine, Yufu, Japan.<br /><searchLink fieldCode="AU" term="%22Perera+SA%22">Perera SA</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Husain+R%22">Husain R</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+TTL%22">Wong TTL</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ho+CL%22">Ho CL</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Abu-Amero+K%22">Abu-Amero K</searchLink>; Department of Research, King Khaled Eye Specialist Hospital and Research Center, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Wong+HT%22">Wong HT</searchLink>; Dept of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Melo+MB%22">Melo MB</searchLink>; Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Hien+NDTN%22">Hien NDTN</searchLink>; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Van+Trinh+N%22">Van Trinh N</searchLink>; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Huong+NTT%22">Huong NTT</searchLink>; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Azhany+Y%22">Azhany Y</searchLink>; Department of Ophthalmology and Visual Science, School of Medical Sciences, Health campus, Universiti Sains Malaysia and Hospital Pakar Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.<br /><searchLink fieldCode="AU" term="%22Perez-Grossmann+R%22">Perez-Grossmann R</searchLink>; Instituto de Glaucoma y Catarata, Lima, Perú.<br /><searchLink fieldCode="AU" term="%22Chan+PP%22">Chan PP</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Stuart+KV%22">Stuart KV</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK.<br /><searchLink fieldCode="AU" term="%22Biradar+MI%22">Biradar MI</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK.<br /><searchLink fieldCode="AU" term="%22Szabo+A%22">Szabo A</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK.<br /><searchLink fieldCode="AU" term="%22Anastasopoulos+E%22">Anastasopoulos E</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Giannoulis+DA%22">Giannoulis DA</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Ntonti+P%22">Ntonti P</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Papakonstantinou+E%22">Papakonstantinou E</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Lambropoulos+A%22">Lambropoulos A</searchLink>; Laboratory of Medical Biology - Genetics, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Chatzikyriakidou+A%22">Chatzikyriakidou A</searchLink>; Laboratory of Medical Biology - Genetics, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Kilintzis+V%22">Kilintzis V</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Ayub+H%22">Ayub H</searchLink>; Department of Biological and Health Sciences, Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Mang, Haripur, KPK, Pakistan.<br /><searchLink fieldCode="AU" term="%22Micheal+S%22">Micheal S</searchLink>; Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Aung+YY%22">Aung YY</searchLink>; Mandalay Eye department, Mandalay Eye ENT hospital, University of Medicine Mandalay, Mandalay, Myanmar.<br /><searchLink fieldCode="AU" term="%22Leuenberger+EU%22">Leuenberger EU</searchLink>; Asian Eye Institute, Manila, Philippines.; University of the East Ramon Magsaysay College of Medicine, Manila, Philippines.<br /><searchLink fieldCode="AU" term="%22Fea+A%22">Fea A</searchLink>; Dipartimento di Scienze Chirurgiche - Universita' di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Mon+NN%22">Mon NN</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Anajao+A%22">Anajao A</searchLink>; Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Bi+X%22">Bi X</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kok+YJ%22">Kok YJ</searchLink>; Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+RS%22">Chong RS</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Boey+PY%22">Boey PY</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+DZJ%22">Tan DZJ</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Sin+WWL%22">Sin WWL</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chowbay+B%22">Chowbay B</searchLink>; National Cancer Centre of, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Khaing+CC%22">Khaing CC</searchLink>; Department of Ophthalmology, No(1) Defence Services General Hospital, Yangon, Myanmar.<br /><searchLink fieldCode="AU" term="%22Aung+YM%22">Aung YM</searchLink>; Myanmar Eye Centre, Grand Hantha International Hospital, Yangon, Myanmar.; University Hospitals Coventry and Warwickshire Trust, Coventry, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Reyes+RD%22">Reyes RD</searchLink>; Department of Ophthalmology/Glaucoma Section, Asian Hospital & Medical Center, Muntinlupa City, Philippines.<br /><searchLink fieldCode="AU" term="%22Panagiotou+ES%22">Panagiotou ES</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Mikropoulos+DG%22">Mikropoulos DG</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Voudouragkaki+IC%22">Voudouragkaki IC</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Panos+GD%22">Panos GD</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Division of Ophthalmology and Visual Sciences, School of Medicine, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Xie+Z%22">Xie Z</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+XY%22">Chen XY</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+YT%22">Lim YT</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Meah+WY%22">Meah WY</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+YS%22">Lee YS</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ho+CEH%22">Ho CEH</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yeo+PMX%22">Yeo PMX</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ikeda+Y%22">Ikeda Y</searchLink>; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Tokuda+Y%22">Tokuda Y</searchLink>; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+M%22">Tanaka M</searchLink>; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Omi+N%22">Omi N</searchLink>; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ueno+M%22">Ueno M</searchLink>; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22de+Vasconcellos+JPC%22">de Vasconcellos JPC</searchLink>; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa+VP%22">Costa VP</searchLink>; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Abe+RY%22">Abe RY</searchLink>; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+BB%22">de Souza BB</searchLink>; Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Fong+GB%22">Fong GB</searchLink>; Instituto de Ciencias Medicas, Lima, Perú.<br /><searchLink fieldCode="AU" term="%22Castro+VV%22">Castro VV</searchLink>; Hospital Nacional Arzobispo Loayza, Lima, Perú.<br /><searchLink fieldCode="AU" term="%22Fujita+R%22">Fujita R</searchLink>; Centro de Genetica y Biologia Molecular, Universidad de San Martin de Porres, Lima, Perú.<br /><searchLink fieldCode="AU" term="%22Guevara-Fujita+ML%22">Guevara-Fujita ML</searchLink>; Centro de Genetica y Biologia Molecular, Universidad de San Martin de Porres, Lima, Perú.<br /><searchLink fieldCode="AU" term="%22Akhtar+F%22">Akhtar F</searchLink>; Department of Glaucoma, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ali+M%22">Ali M</searchLink>; Department of Glaucoma, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Catacutan+MAT%22">Catacutan MAT</searchLink>; Asian Eye Institute, Manila, Philippines.<br /><searchLink fieldCode="AU" term="%22Felarca+IR%22">Felarca IR</searchLink>; Asian Eye Institute, Manila, Philippines.<br /><searchLink fieldCode="AU" term="%22Liao+CS%22">Liao CS</searchLink>; Asian Eye Institute, Manila, Philippines.<br /><searchLink fieldCode="AU" term="%22Lavia+C%22">Lavia C</searchLink>; Dipartimento di Scienze Chirurgiche - Universita' di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Than+HM%22">Than HM</searchLink>; Department of Ophthalmology, North Okkalarpa General Hospital, Yangon, Myanmar.<br /><searchLink fieldCode="AU" term="%22Oo+KT%22">Oo KT</searchLink>; Myanmar Eye Centre, Grand Hantha International Hospital, Yangon, Myanmar.<br /><searchLink fieldCode="AU" term="%22Soe-Kyaw+PP%22">Soe-Kyaw PP</searchLink>; Myanmar Eye Centre, Grand Hantha International Hospital, Yangon, Myanmar.<br /><searchLink fieldCode="AU" term="%22Frezzotti+P%22">Frezzotti P</searchLink>; Surgery Department, Section of Ophthalmology, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Pasutto+F%22">Pasutto F</searchLink>; Humangenetisches Institut, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Kussmaulallee 4, 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Quino+R%22">Quino R</searchLink>; Department of Ophthalmology/Glaucoma Section, Asian Hospital & Medical Center, Muntinlupa City, Philippines.; University of the Philippines- College of Medicine, Manila, Philippines.<br /><searchLink fieldCode="AU" term="%22Minn-Din+Z%22">Minn-Din Z</searchLink>; Myanmar Eye Centre, Grand Hantha International Hospital, Yangon, Myanmar.<br /><searchLink fieldCode="AU" term="%22Oo+NL%22">Oo NL</searchLink>; Department of Ophthalmology, No(1) Defence Services General Hospital, Yangon, Myanmar.<br /><searchLink fieldCode="AU" term="%22Dallorto+L%22">Dallorto L</searchLink>; Dipartimento di Scienze Chirurgiche - Universita' di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Set+SH%22">Set SH</searchLink>; Mandalay Eye department, Mandalay Eye ENT hospital, University of Medicine Mandalay, Mandalay, Myanmar.<br /><searchLink fieldCode="AU" term="%22Doan+VH%22">Doan VH</searchLink>; Hue University of Medicine and Pharmacy, Danang City, Vietnam.<br /><searchLink fieldCode="AU" term="%22Qamar+R%22">Qamar R</searchLink>; Science and Environment Sector, ICESCO, Rabat, Morocco.; Pakistan Academy of Sciences, Islamabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Neto+JM%22">Neto JM</searchLink>; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Al-Obeidan+S%22">Al-Obeidan S</searchLink>; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Tham+CC%22">Tham CC</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Mori+K%22">Mori K</searchLink>; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sotozono+C%22">Sotozono C</searchLink>; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kinoshita+S%22">Kinoshita S</searchLink>; Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Konstas+AG%22">Konstas AG</searchLink>; 1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Liza-Sharmini+AT%22">Liza-Sharmini AT</searchLink>; Department of Ophthalmology and Visual Science, School of Medical Sciences, Health campus, Universiti Sains Malaysia and Hospital Pakar Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.<br /><searchLink fieldCode="AU" term="%22Zenteno+JC%22">Zenteno JC</searchLink>; Rare Disease Diagnostic Unit/Biochemistry Department, Faculty of Medicine, UNAM, Mexico City, Mexico.; Genetics Department, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Do+NH%22">Do NH</searchLink>; Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Foster+PJ%22">Foster PJ</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK.<br /><searchLink fieldCode="AU" term="%22Tashiro+K%22">Tashiro K</searchLink>; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Pang+CP%22">Pang CP</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Khawaja+AP%22">Khawaja AP</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK.<br /><searchLink fieldCode="AU" term="%22Aung+T%22">Aung T</searchLink>; Duke-NUS Medical School, National University of, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore. zhenxun.wang@duke-nus.edu.sg.; Duke-NUS Medical School, National University of, Singapore, Singapore. zhenxun.wang@duke-nus.edu.sg.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. zhenxun.wang@duke-nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Khor+CC%22">Khor CC</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, 138672, Republic of Singapore. khorcc@a-star.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Aug 15; Vol. 16 (1), pp. 7620. <i>Date of Electronic Publication: </i>2025 Aug 15.
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      – TitleFull: Functionally deficient UBOX5 variants and primary angle-closure glaucoma.
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            NameFull: Neto JM
      – PersonEntity:
          Name:
            NameFull: Al-Obeidan S
      – PersonEntity:
          Name:
            NameFull: Tham CC
      – PersonEntity:
          Name:
            NameFull: Mori K
      – PersonEntity:
          Name:
            NameFull: Sotozono C
      – PersonEntity:
          Name:
            NameFull: Kinoshita S
      – PersonEntity:
          Name:
            NameFull: Konstas AG
      – PersonEntity:
          Name:
            NameFull: Liza-Sharmini AT
      – PersonEntity:
          Name:
            NameFull: Zenteno JC
      – PersonEntity:
          Name:
            NameFull: Do NH
      – PersonEntity:
          Name:
            NameFull: Foster PJ
      – PersonEntity:
          Name:
            NameFull: Tashiro K
      – PersonEntity:
          Name:
            NameFull: Pang CP
      – PersonEntity:
          Name:
            NameFull: Khawaja AP
      – PersonEntity:
          Name:
            NameFull: Aung T
      – PersonEntity:
          Name:
            NameFull: Wang Z
      – PersonEntity:
          Name:
            NameFull: Khor CC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 08
              Text: 2025 Aug 15
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1