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Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real-World Data Utilization.

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Title: Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real-World Data Utilization.
Authors: Su L; Merck & Co., Inc., Rahway, New Jersey, USA., Chen L; Merck & Co., Inc., Rahway, New Jersey, USA., Betigeri S; Merck & Co., Inc., Rahway, New Jersey, USA., Dreyer N; Dreyer Strategies LLC, Newton, Massachusetts, USA., Gardarsdottir H; Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands., Hendricks-Sturrup R; Duke-Robert J. Margolis Institute for Health Policy, Duke University, Washington, DC, USA., Burcu M; Merck & Co., Inc., Rahway, New Jersey, USA.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2025 Dec; Vol. 118 (6), pp. 1350-1365. Date of Electronic Publication: 2025 Aug 19.
Publication Type: Journal Article; Review
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real-World Data Utilization.
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  Data: <searchLink fieldCode="AU" term="%22Su+L%22">Su L</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Betigeri+S%22">Betigeri S</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Dreyer+N%22">Dreyer N</searchLink>; Dreyer Strategies LLC, Newton, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gardarsdottir+H%22">Gardarsdottir H</searchLink>; Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hendricks-Sturrup+R%22">Hendricks-Sturrup R</searchLink>; Duke-Robert J. Margolis Institute for Health Policy, Duke University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Burcu+M%22">Burcu M</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.
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  Data: <searchLink fieldCode="JN" term="%220372741%22">Clinical pharmacology and therapeutics</searchLink> [Clin Pharmacol Ther] 2025 Dec; Vol. 118 (6), pp. 1350-1365. <i>Date of Electronic Publication: </i>2025 Aug 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372741 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-6535 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200099236%22">00099236 </searchLink><i>NLM ISO Abbreviation: </i>Clin Pharmacol Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1002/cpt.70033
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      – Code: eng
        Text: English
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              Text: 2025 Dec
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