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STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD.

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Title: STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD.
Authors: Kelepouras K; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany., Saggau J; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany., Bonasera D; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany., Kiefer C; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany., Locci F; Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany., Rakhsh-Khorshid H; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany., Grauvogel L; Department of Translational Genomics, Centre of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany., Varanda AB; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany., Peifer M; Department of Translational Genomics, Centre of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany., Loricchio E; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Montinaro A; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK., Croon M; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Institute for Mitochondrial Diseases and Ageing, Medical Faculty and Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Trifunovic A; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Institute for Mitochondrial Diseases and Ageing, Medical Faculty and Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Prencipe G; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Insalaco A; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., De Benedetti F; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Walczak H; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK., Liccardi G; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de.
Source: Nature [Nature] 2025 Nov; Vol. 647 (8090), pp. 735-746. Date of Electronic Publication: 2025 Aug 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD.
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  Data: <searchLink fieldCode="AU" term="%22Kelepouras+K%22">Kelepouras K</searchLink>; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Saggau+J%22">Saggau J</searchLink>; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Bonasera+D%22">Bonasera D</searchLink>; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kiefer+C%22">Kiefer C</searchLink>; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Locci+F%22">Locci F</searchLink>; Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Rakhsh-Khorshid+H%22">Rakhsh-Khorshid H</searchLink>; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Grauvogel+L%22">Grauvogel L</searchLink>; Department of Translational Genomics, Centre of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Varanda+AB%22">Varanda AB</searchLink>; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Peifer+M%22">Peifer M</searchLink>; Department of Translational Genomics, Centre of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Loricchio+E%22">Loricchio E</searchLink>; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Montinaro+A%22">Montinaro A</searchLink>; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Croon+M%22">Croon M</searchLink>; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Institute for Mitochondrial Diseases and Ageing, Medical Faculty and Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Trifunovic+A%22">Trifunovic A</searchLink>; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Institute for Mitochondrial Diseases and Ageing, Medical Faculty and Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Prencipe+G%22">Prencipe G</searchLink>; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Insalaco+A%22">Insalaco A</searchLink>; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Benedetti+F%22">De Benedetti F</searchLink>; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Walczak+H%22">Walczak H</searchLink>; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Liccardi+G%22">Liccardi G</searchLink>; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de.
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