STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD.
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| Title: | STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD. |
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| Authors: | Kelepouras K; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany., Saggau J; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany., Bonasera D; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany., Kiefer C; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany., Locci F; Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany., Rakhsh-Khorshid H; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany., Grauvogel L; Department of Translational Genomics, Centre of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany., Varanda AB; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany., Peifer M; Department of Translational Genomics, Centre of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany., Loricchio E; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Montinaro A; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK., Croon M; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Institute for Mitochondrial Diseases and Ageing, Medical Faculty and Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Trifunovic A; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.; Institute for Mitochondrial Diseases and Ageing, Medical Faculty and Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Prencipe G; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Insalaco A; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., De Benedetti F; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Walczak H; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK., Liccardi G; Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de.; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de. |
| Source: | Nature [Nature] 2025 Nov; Vol. 647 (8090), pp. 735-746. Date of Electronic Publication: 2025 Aug 20. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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