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SLC45A4 is a pain gene encoding a neuronal polyamine transporter.

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Title: SLC45A4 is a pain gene encoding a neuronal polyamine transporter.
Authors: Middleton SJ; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK., Markússon S; Department of Biochemistry, University of Oxford, Oxford, UK.; The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Åkerlund M; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden., Deme JC; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Tseng M; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK., Li W; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK., Zuberi SR; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK., Kuteyi G; Department of Biochemistry, University of Oxford, Oxford, UK.; The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Sarkies P; Department of Biochemistry, University of Oxford, Oxford, UK., Baskozos G; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK., Perez-Sanchez J; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK., Farah A; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK., Hébert HL; Chronic Pain Research Group, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Toikumo S; Mental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Yu Z; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Maxwell S; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK., Dong YY; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK., Kessler BM; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kranzler HR; Mental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Linley JE; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Smith BH; Chronic Pain Research Group, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Lea SM; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Parker JL; Department of Biochemistry, University of Oxford, Oxford, UK.; The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Lyssenko V; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway.; Steno Diabetes Center Copenhagen, Herlev, Denmark., Newstead S; Department of Biochemistry, University of Oxford, Oxford, UK. Simon.newstead@bioch.ox.ac.uk.; The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. Simon.newstead@bioch.ox.ac.uk., Bennett DL; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK. David.bennett@ndcn.ox.ac.uk.
Source: Nature [Nature] 2025 Oct; Vol. 646 (8084), pp. 404-412. Date of Electronic Publication: 2025 Aug 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Middleton+SJ%22">Middleton SJ</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Markússon+S%22">Markússon S</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK.; The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Åkerlund+M%22">Åkerlund M</searchLink>; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Deme+JC%22">Deme JC</searchLink>; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tseng+M%22">Tseng M</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Zuberi+SR%22">Zuberi SR</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kuteyi+G%22">Kuteyi G</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK.; The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sarkies+P%22">Sarkies P</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Baskozos+G%22">Baskozos G</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Perez-Sanchez+J%22">Perez-Sanchez J</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Farah+A%22">Farah A</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hébert+HL%22">Hébert HL</searchLink>; Chronic Pain Research Group, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Toikumo+S%22">Toikumo S</searchLink>; Mental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+Z%22">Yu Z</searchLink>; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Maxwell+S%22">Maxwell S</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dong+YY%22">Dong YY</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kessler+BM%22">Kessler BM</searchLink>; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kranzler+HR%22">Kranzler HR</searchLink>; Mental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Linley+JE%22">Linley JE</searchLink>; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Smith+BH%22">Smith BH</searchLink>; Chronic Pain Research Group, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Lea+SM%22">Lea SM</searchLink>; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Parker+JL%22">Parker JL</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK.; The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lyssenko+V%22">Lyssenko V</searchLink>; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway.; Steno Diabetes Center Copenhagen, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Newstead+S%22">Newstead S</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK. Simon.newstead@bioch.ox.ac.uk.; The Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. Simon.newstead@bioch.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Bennett+DL%22">Bennett DL</searchLink>; Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK. David.bennett@ndcn.ox.ac.uk.
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