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Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity.

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Title: Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity.
Authors: Lunavat TR; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Biomedicine, University of Bergen, 5019 Bergen, Norway., Nieland L; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Neurosurgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., van de Looij SM; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., de Reus AJEM; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., Couturier CP; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Institute of Medical Engineering and Sciences and Department of Chemistry, Massachusetts Institute Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institutes of Technology, Cambridge, MA 02139, USA; Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada., El Farran CA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02215, USA; Ludwig Center at Harvard Medical School, Boston, MA 02215, USA., Miller TE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02215, USA; Ludwig Center at Harvard Medical School, Boston, MA 02215, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Lill JK; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., Schübel M; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., Xiao T; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., Di Ianni E; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., Woods EC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Sun Y; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Rufino-Ramos D; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Harvard Medical School, Boston, MA 02115, USA., van Solinge TS; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Neurosurgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Mahjoum S; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., Grandell E; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., Li M; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Brain Tumor Immunology and Immunotherapy Program, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Mangena V; Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA., Dunn GP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Brain Tumor Immunology and Immunotherapy Program, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Jenkins RW; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Mempel TR; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., Breakefield XO; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA., Breyne K; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. Electronic address: kbreyne@mgh.harvard.edu.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Nov 05; Vol. 33 (11), pp. 5530-5555. Date of Electronic Publication: 2025 Aug 20.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity.
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  Data: <searchLink fieldCode="AU" term="%22Lunavat+TR%22">Lunavat TR</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Biomedicine, University of Bergen, 5019 Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Nieland+L%22">Nieland L</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Neurosurgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Looij+SM%22">van de Looij SM</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22de+Reus+AJEM%22">de Reus AJEM</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Couturier+CP%22">Couturier CP</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Institute of Medical Engineering and Sciences and Department of Chemistry, Massachusetts Institute Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institutes of Technology, Cambridge, MA 02139, USA; Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22El+Farran+CA%22">El Farran CA</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02215, USA; Ludwig Center at Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Miller+TE%22">Miller TE</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02215, USA; Ludwig Center at Harvard Medical School, Boston, MA 02215, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Lill+JK%22">Lill JK</searchLink>; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Schübel+M%22">Schübel M</searchLink>; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+T%22">Xiao T</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Di+Ianni+E%22">Di Ianni E</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Woods+EC%22">Woods EC</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Rufino-Ramos+D%22">Rufino-Ramos D</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22van+Solinge+TS%22">van Solinge TS</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Neurosurgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mahjoum+S%22">Mahjoum S</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Grandell+E%22">Grandell E</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Brain Tumor Immunology and Immunotherapy Program, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Mangena+V%22">Mangena V</searchLink>; Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Dunn+GP%22">Dunn GP</searchLink>; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Brain Tumor Immunology and Immunotherapy Program, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Jenkins+RW%22">Jenkins RW</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Mempel+TR%22">Mempel TR</searchLink>; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Breakefield+XO%22">Breakefield XO</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Breyne+K%22">Breyne K</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. Electronic address: kbreyne@mgh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2025 Nov 05; Vol. 33 (11), pp. 5530-5555. <i>Date of Electronic Publication: </i>2025 Aug 20.
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