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A multifunctional hydrogel promotes diabetic wound healing by remodeling iron balance and energy metabolism.

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Title: A multifunctional hydrogel promotes diabetic wound healing by remodeling iron balance and energy metabolism.
Authors: Jin C; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China., Lin YZ; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China., Zhang RY; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China., Zhang DP; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Xue KK; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Xu J; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Jiang XQ; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Han LJ; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China., Liu LY; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China., Shi YF; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China., Jin MQ; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Miu JS; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China., Lu YF; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China., Cai LY; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China., Lin Z; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China; Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address: linzhen@smu.edu.cn., Yang L; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. Electronic address: yanglei@wmu.edu.cn., Xiao J; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. Electronic address: xfxj2000@126.com.
Source: Biomaterials [Biomaterials] 2026 Mar; Vol. 326, pp. 123640. Date of Electronic Publication: 2025 Aug 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A multifunctional hydrogel promotes diabetic wound healing by remodeling iron balance and energy metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Jin+C%22">Jin C</searchLink>; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.<br /><searchLink fieldCode="AU" term="%22Lin+YZ%22">Lin YZ</searchLink>; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.<br /><searchLink fieldCode="AU" term="%22Zhang+RY%22">Zhang RY</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.<br /><searchLink fieldCode="AU" term="%22Zhang+DP%22">Zhang DP</searchLink>; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Xue+KK%22">Xue KK</searchLink>; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Jiang+XQ%22">Jiang XQ</searchLink>; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Han+LJ%22">Han LJ</searchLink>; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.<br /><searchLink fieldCode="AU" term="%22Liu+LY%22">Liu LY</searchLink>; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.<br /><searchLink fieldCode="AU" term="%22Shi+YF%22">Shi YF</searchLink>; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.<br /><searchLink fieldCode="AU" term="%22Jin+MQ%22">Jin MQ</searchLink>; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Miu+JS%22">Miu JS</searchLink>; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.<br /><searchLink fieldCode="AU" term="%22Lu+YF%22">Lu YF</searchLink>; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China.<br /><searchLink fieldCode="AU" term="%22Cai+LY%22">Cai LY</searchLink>; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.<br /><searchLink fieldCode="AU" term="%22Lin+Z%22">Lin Z</searchLink>; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China; Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address: linzhen@smu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. Electronic address: yanglei@wmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xiao+J%22">Xiao J</searchLink>; Department of Wound healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), National Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. Electronic address: xfxj2000@126.com.
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  Data: <searchLink fieldCode="JN" term="%228100316%22">Biomaterials</searchLink> [Biomaterials] 2026 Mar; Vol. 326, pp. 123640. <i>Date of Electronic Publication: </i>2025 Aug 19.
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