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Molecular basis of potent antiviral HLA-C-restricted CD8+ T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope.

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Title: Molecular basis of potent antiviral HLA-C-restricted CD8+ T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope.
Authors: Goto Y; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.; Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, 8608556, Japan., Ahn YM; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia., Toyoda M; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan., Hamana H; Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, 9300194, Japan., Jin Y; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan., Aritsu Y; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan., Nakama T; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan., Tajima Y; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.; Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, 8608556, Japan., Maddumage JC; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia., Li H; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan., Kitamatsu M; Department of Applied Chemistry, Faculty of Science and Engineering, Kindai University, Osaka, 577-8502, Japan., Kishi H; Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, 9300194, Japan., Yonekawa A; Center for the Study of Global Infection, Kyushu University Hospital, Kyushu University, Fukuoka, 8128582, Japan., Jayasinghe D; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia., Shimono N; Center for the Study of Global Infection, Kyushu University Hospital, Kyushu University, Fukuoka, 8128582, Japan., Nagasaki Y; Division of Infectious Diseases, Clinical Research Institute, National Hospitalization Organization, Kyushu Medical Center, Fukuoka, 8108563, Japan., Minami R; Internal Medicine, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, 8108563, Japan., Toya T; Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, 1138677, Japan., Sekiya N; Department of Infection Prevention and Control, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, 1138677, Japan.; Department of Infectious Disease Emergency Preparedness, Institute of Science Tokyo, Tokyo, 1138510, Japan., Tomita Y; Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, 8608556, Japan., Chatzileontiadou DSM; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia., Nakata H; Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto University Hospital, Kumamoto, 8608556, Japan., Nakagawa S; Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, 2591193, Japan., Sakagami T; Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, 8608556, Japan., Ueno T; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan., Gras S; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia. S.Gras@latrobe.edu.au.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia. S.Gras@latrobe.edu.au.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia. S.Gras@latrobe.edu.au., Motozono C; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan. motozono@kumamoto-u.ac.jp.
Source: Nature communications [Nat Commun] 2025 Aug 28; Vol. 16 (1), pp. 8062. Date of Electronic Publication: 2025 Aug 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Molecular basis of potent antiviral HLA-C-restricted CD8<superscript>+</superscript> T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope.
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  Data: <searchLink fieldCode="AU" term="%22Goto+Y%22">Goto Y</searchLink>; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.; Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, 8608556, Japan.<br /><searchLink fieldCode="AU" term="%22Ahn+YM%22">Ahn YM</searchLink>; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Toyoda+M%22">Toyoda M</searchLink>; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.<br /><searchLink fieldCode="AU" term="%22Hamana+H%22">Hamana H</searchLink>; Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, 9300194, Japan.<br /><searchLink fieldCode="AU" term="%22Jin+Y%22">Jin Y</searchLink>; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.<br /><searchLink fieldCode="AU" term="%22Aritsu+Y%22">Aritsu Y</searchLink>; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.<br /><searchLink fieldCode="AU" term="%22Nakama+T%22">Nakama T</searchLink>; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.<br /><searchLink fieldCode="AU" term="%22Tajima+Y%22">Tajima Y</searchLink>; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.; Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, 8608556, Japan.<br /><searchLink fieldCode="AU" term="%22Maddumage+JC%22">Maddumage JC</searchLink>; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.<br /><searchLink fieldCode="AU" term="%22Kitamatsu+M%22">Kitamatsu M</searchLink>; Department of Applied Chemistry, Faculty of Science and Engineering, Kindai University, Osaka, 577-8502, Japan.<br /><searchLink fieldCode="AU" term="%22Kishi+H%22">Kishi H</searchLink>; Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, 9300194, Japan.<br /><searchLink fieldCode="AU" term="%22Yonekawa+A%22">Yonekawa A</searchLink>; Center for the Study of Global Infection, Kyushu University Hospital, Kyushu University, Fukuoka, 8128582, Japan.<br /><searchLink fieldCode="AU" term="%22Jayasinghe+D%22">Jayasinghe D</searchLink>; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Shimono+N%22">Shimono N</searchLink>; Center for the Study of Global Infection, Kyushu University Hospital, Kyushu University, Fukuoka, 8128582, Japan.<br /><searchLink fieldCode="AU" term="%22Nagasaki+Y%22">Nagasaki Y</searchLink>; Division of Infectious Diseases, Clinical Research Institute, National Hospitalization Organization, Kyushu Medical Center, Fukuoka, 8108563, Japan.<br /><searchLink fieldCode="AU" term="%22Minami+R%22">Minami R</searchLink>; Internal Medicine, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, 8108563, Japan.<br /><searchLink fieldCode="AU" term="%22Toya+T%22">Toya T</searchLink>; Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, 1138677, Japan.<br /><searchLink fieldCode="AU" term="%22Sekiya+N%22">Sekiya N</searchLink>; Department of Infection Prevention and Control, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, 1138677, Japan.; Department of Infectious Disease Emergency Preparedness, Institute of Science Tokyo, Tokyo, 1138510, Japan.<br /><searchLink fieldCode="AU" term="%22Tomita+Y%22">Tomita Y</searchLink>; Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, 8608556, Japan.<br /><searchLink fieldCode="AU" term="%22Chatzileontiadou+DSM%22">Chatzileontiadou DSM</searchLink>; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Nakata+H%22">Nakata H</searchLink>; Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto University Hospital, Kumamoto, 8608556, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagawa+S%22">Nakagawa S</searchLink>; Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, 2591193, Japan.<br /><searchLink fieldCode="AU" term="%22Sakagami+T%22">Sakagami T</searchLink>; Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, 8608556, Japan.<br /><searchLink fieldCode="AU" term="%22Ueno+T%22">Ueno T</searchLink>; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan.<br /><searchLink fieldCode="AU" term="%22Gras+S%22">Gras S</searchLink>; Immunity and Infection program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC, 3086, Australia. S.Gras@latrobe.edu.au.; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, 3086, Australia. S.Gras@latrobe.edu.au.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia. S.Gras@latrobe.edu.au.<br /><searchLink fieldCode="AU" term="%22Motozono+C%22">Motozono C</searchLink>; Division of Infection and immunity, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, 8600811, Japan. motozono@kumamoto-u.ac.jp.
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