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Engineered monoclonal antibody tobevibart enhances HBsAg capture by Fc receptor-positive cells and activates HBV-specific T cells.

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Title: Engineered monoclonal antibody tobevibart enhances HBsAg capture by Fc receptor-positive cells and activates HBV-specific T cells.
Authors: Vincenzetti L; Vir Biotechnology, Bellinzona, Switzerland., Wong R; Vir Biotechnology, San Francisco, California, USA., Marzi R; Vir Biotechnology, Bellinzona, Switzerland., Guarino B; Vir Biotechnology, Bellinzona, Switzerland., Stefanutti E; Vir Biotechnology, San Francisco, California, USA., Gupta SV; Vir Biotechnology, San Francisco, California, USA., Rosen LE; Vir Biotechnology, San Francisco, California, USA., Belnap DM; School of Biological Sciences and Department of Biochemistry, University of Utah, Utah, USA., Wang L; Vir Biotechnology, San Francisco, California, USA., Chen YP; Vir Biotechnology, San Francisco, California, USA., di Iulio J; Vir Biotechnology, San Francisco, California, USA., Momin A; Vir Biotechnology, San Francisco, California, USA., Tracy KE; Vir Biotechnology, San Francisco, California, USA., Deshpande S; Vir Biotechnology, San Francisco, California, USA., Errico JM; Vir Biotechnology, San Francisco, California, USA., Giovannoni F; Vir Biotechnology, Bellinzona, Switzerland., Sprugasci N; Vir Biotechnology, Bellinzona, Switzerland., Peter A; Vir Biotechnology, Bellinzona, Switzerland., Seu L; Vir Biotechnology, San Francisco, California, USA., Cloutier D; Vir Biotechnology, San Francisco, California, USA., Tay CH; Vir Biotechnology, San Francisco, California, USA., Snell G; Vir Biotechnology, San Francisco, California, USA., Czudnochowski N; Vir Biotechnology, San Francisco, California, USA., Lempp FA; Vir Biotechnology, Bellinzona, Switzerland; Vir Biotechnology, San Francisco, California, USA., Havenar-Daughton C; Vir Biotechnology, San Francisco, California, USA., Benigni F; Vir Biotechnology, Bellinzona, Switzerland., Lanzavecchia A; Vir Biotechnology, Bellinzona, Switzerland., Agarwal K; Institute of Liver Studies, King's College Hospital, London, UK., Yuen MF; Department of Medicine, Queen Mary Hospital, University of Hong Kong, China., Wedemeyer H; Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Germany., Gane E; Faculty of Medicine, University of Auckland, New Zealand., Arvin A; Vir Biotechnology, San Francisco, California, USA., Corti D; Vir Biotechnology, Bellinzona, Switzerland., Schmid MA; Vir Biotechnology, Bellinzona, Switzerland. Electronic address: mschmid@vir.bio.
Source: Journal of hepatology [J Hepatol] 2026 Jan; Vol. 84 (1), pp. 62-73. Date of Electronic Publication: 2025 Aug 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineered monoclonal antibody tobevibart enhances HBsAg capture by Fc receptor-positive cells and activates HBV-specific T cells.
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  Data: <searchLink fieldCode="AU" term="%22Vincenzetti+L%22">Vincenzetti L</searchLink>; Vir Biotechnology, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wong+R%22">Wong R</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Marzi+R%22">Marzi R</searchLink>; Vir Biotechnology, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guarino+B%22">Guarino B</searchLink>; Vir Biotechnology, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stefanutti+E%22">Stefanutti E</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+SV%22">Gupta SV</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+LE%22">Rosen LE</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Belnap+DM%22">Belnap DM</searchLink>; School of Biological Sciences and Department of Biochemistry, University of Utah, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Chen+YP%22">Chen YP</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22di+Iulio+J%22">di Iulio J</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Momin+A%22">Momin A</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Tracy+KE%22">Tracy KE</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Deshpande+S%22">Deshpande S</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Errico+JM%22">Errico JM</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Giovannoni+F%22">Giovannoni F</searchLink>; Vir Biotechnology, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sprugasci+N%22">Sprugasci N</searchLink>; Vir Biotechnology, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Peter+A%22">Peter A</searchLink>; Vir Biotechnology, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Seu+L%22">Seu L</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Cloutier+D%22">Cloutier D</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Tay+CH%22">Tay CH</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Snell+G%22">Snell G</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Czudnochowski+N%22">Czudnochowski N</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Lempp+FA%22">Lempp FA</searchLink>; Vir Biotechnology, Bellinzona, Switzerland; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Havenar-Daughton+C%22">Havenar-Daughton C</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Benigni+F%22">Benigni F</searchLink>; Vir Biotechnology, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lanzavecchia+A%22">Lanzavecchia A</searchLink>; Vir Biotechnology, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Agarwal+K%22">Agarwal K</searchLink>; Institute of Liver Studies, King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Yuen+MF%22">Yuen MF</searchLink>; Department of Medicine, Queen Mary Hospital, University of Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Wedemeyer+H%22">Wedemeyer H</searchLink>; Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Germany.<br /><searchLink fieldCode="AU" term="%22Gane+E%22">Gane E</searchLink>; Faculty of Medicine, University of Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Arvin+A%22">Arvin A</searchLink>; Vir Biotechnology, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Corti+D%22">Corti D</searchLink>; Vir Biotechnology, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schmid+MA%22">Schmid MA</searchLink>; Vir Biotechnology, Bellinzona, Switzerland. Electronic address: mschmid@vir.bio.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2026 Jan; Vol. 84 (1), pp. 62-73. <i>Date of Electronic Publication: </i>2025 Aug 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8503886 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1600-0641 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201688278%22">01688278 </searchLink><i>NLM ISO Abbreviation: </i>J Hepatol <i>Subsets: </i>MEDLINE
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