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Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells.

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Title: Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells.
Authors: Ozel I; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany., Sha G; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany., Będzińska A; Center for Translational Research and Molecular Biology of Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, 44101, Poland., Pylaeva E; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany., Naumova Y; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany., Thiel I; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany., Antczak J; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany., Squire A; Institute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, 45141, Germany., Gunzer M; Institute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, 45141, Germany., Zelinskyy G; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, 45147, Germany., Kürten C; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany., Lang S; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.; German Cancer Consortium (DKTK) partner site Düsseldorf/Essen, Essen, 45147, Germany., Silvestre-Roig C; Institute of Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, 48149, Germany., Kortylewski M; Department of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.; Center for Gene Therapy, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA., Granot Z; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Faculty of Medicine, Hebrew University, Jerusalem, 91120, Israel., Jablonska J; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany. jadwiga.jablonska@uk-essen.de.; German Cancer Consortium (DKTK) partner site Düsseldorf/Essen, Essen, 45147, Germany. jadwiga.jablonska@uk-essen.de.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2025 Aug 30; Vol. 10 (1), pp. 279. Date of Electronic Publication: 2025 Aug 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8<superscript>+</superscript> T cells.
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  Data: <searchLink fieldCode="AU" term="%22Ozel+I%22">Ozel I</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Sha+G%22">Sha G</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Będzińska+A%22">Będzińska A</searchLink>; Center for Translational Research and Molecular Biology of Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, 44101, Poland.<br /><searchLink fieldCode="AU" term="%22Pylaeva+E%22">Pylaeva E</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Naumova+Y%22">Naumova Y</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Thiel+I%22">Thiel I</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Antczak+J%22">Antczak J</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Squire+A%22">Squire A</searchLink>; Institute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, 45141, Germany.<br /><searchLink fieldCode="AU" term="%22Gunzer+M%22">Gunzer M</searchLink>; Institute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, 45141, Germany.<br /><searchLink fieldCode="AU" term="%22Zelinskyy+G%22">Zelinskyy G</searchLink>; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Kürten+C%22">Kürten C</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Lang+S%22">Lang S</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.; German Cancer Consortium (DKTK) partner site Düsseldorf/Essen, Essen, 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Silvestre-Roig+C%22">Silvestre-Roig C</searchLink>; Institute of Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, 48149, Germany.<br /><searchLink fieldCode="AU" term="%22Kortylewski+M%22">Kortylewski M</searchLink>; Department of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.; Center for Gene Therapy, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.<br /><searchLink fieldCode="AU" term="%22Granot+Z%22">Granot Z</searchLink>; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Faculty of Medicine, Hebrew University, Jerusalem, 91120, Israel.<br /><searchLink fieldCode="AU" term="%22Jablonska+J%22">Jablonska J</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany. jadwiga.jablonska@uk-essen.de.; German Cancer Consortium (DKTK) partner site Düsseldorf/Essen, Essen, 45147, Germany. jadwiga.jablonska@uk-essen.de.
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