Study protocol: COPD-eosinophil-guided reduction of inhaled corticosteroids (COPERNICOS) : A randomized, double-blinded, multicenter, four-arm intervention clinical trial on eosinophil-guided time-updated person-specific reduction of inhaled corticosteroid therapy and prophylactic low dose Azithromycin therapy in patients with severe or very severe chronic obstructive pulmonary disease (COPD). - Rønn C; Bonnesen B; Alispahic IA; Tønnesen LL; Kjærgaard JL; Moberg M; Ulrik CS; Harboe ZB; Browatzki A; Jensen TT; Meyer CN; Bodtger U; et al. (Trials, 2025)