Study protocol: COPD-eosinophil-guided reduction of inhaled corticosteroids (COPERNICOS) : A randomized, double-blinded, multicenter, four-arm intervention clinical trial on eosinophil-guided time-updated person-specific reduction of inhaled corticosteroid therapy and prophylactic low dose Azithromycin therapy in patients with severe or very severe chronic obstructive pulmonary disease (COPD).
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| Title: | Study protocol: COPD-eosinophil-guided reduction of inhaled corticosteroids (COPERNICOS) : A randomized, double-blinded, multicenter, four-arm intervention clinical trial on eosinophil-guided time-updated person-specific reduction of inhaled corticosteroid therapy and prophylactic low dose Azithromycin therapy in patients with severe or very severe chronic obstructive pulmonary disease (COPD). |
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| Authors: | Rønn C; Department of Internal Medicine, Copenhagen Respiratory Research, Copenhagen University Hospital - Gentofte, Hellerup, Denmark. croe0070@regionh.dk., Bonnesen B; Department of Internal Medicine, Copenhagen Respiratory Research, Copenhagen University Hospital - Gentofte, Hellerup, Denmark., Alispahic IA; Department of Internal Medicine, Copenhagen Respiratory Research, Copenhagen University Hospital - Gentofte, Hellerup, Denmark., Tønnesen LL; Department of Internal Medicine, Copenhagen Respiratory Research, Copenhagen University Hospital - Gentofte, Hellerup, Denmark., Kjærgaard JL; Department of Internal Medicine, Copenhagen Respiratory Research, Copenhagen University Hospital - Gentofte, Hellerup, Denmark., Moberg M; Department of Respiratory Medicine, Copenhagen University Hospital - Hvidovre, Hvidovre, Denmark., Ulrik CS; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Respiratory Medicine, Copenhagen University Hospital - Hvidovre, Hvidovre, Denmark., Harboe ZB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Respiratory Medicine and Infectious Medicine, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark., Browatzki A; Department of Respiratory Medicine and Infectious Medicine, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark., Jensen TT; Department of Respiratory Medicine, Hospital of South West Jutland, Esbjerg, Denmark., Meyer CN; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Respiratory Medicine, Zealand University Hospital, Roskilde, Næsteved, Denmark., Bodtger U; Department of Respiratory Medicine, Zealand University Hospital, Roskilde, Næsteved, Denmark., Bendstrup E; Center for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Johansson SL; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark., Kaiser DU; Department of Internal Medicine, Copenhagen University Hospital - Bornholm, Roenne, Denmark., Hyldgaard C; Medical Diagnostic Center, Regional Hospital Central Jutland, Silkeborg, Denmark., Vestbo J; The Allergy and Lung Clinic, Vanløse, Denmark., Sivapalan P; Department of Internal Medicine, Copenhagen Respiratory Research, Copenhagen University Hospital - Gentofte, Hellerup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jensen JS; Department of Internal Medicine, Copenhagen Respiratory Research, Copenhagen University Hospital - Gentofte, Hellerup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. |
| Source: | Trials [Trials] 2025 Sep 02; Vol. 26 (1), pp. 335. Date of Electronic Publication: 2025 Sep 02. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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