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Genetic modifications boost chrexanthomycin yield and neuroprotective potential.

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Title: Genetic modifications boost chrexanthomycin yield and neuroprotective potential.
Authors: Ye W; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China; Key Laboratory of Functional Yeast of China National Light Industry, Hubei Key Laboratory of Natural Products Research and Development, Hubei Engineering Research Center for Bioenzyme Engineering Technology, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China., Ye W; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China., Huang X; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China., Wang J; Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519087, China., She W; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China., Huang D; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China., Liu X; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China., Li J; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China., Qin D; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China., Chik SY; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China., Pan B; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China., Zhang W; State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China., Liu T; State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China., Sung HH; Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong 999077, China., Xu B; Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519087, China., Williams ID; Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong 999077, China., Cheng A; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macao Special Administrative Region, 999078, China; Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macao Special Administrative Region, 999078, China. Electronic address: chengaf@um.edu.mo., Qian P; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China. Electronic address: boqianpy@ust.hk.
Source: Journal of advanced research [J Adv Res] 2026 Jun; Vol. 84, pp. 203-215. Date of Electronic Publication: 2025 Sep 01.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic modifications boost chrexanthomycin yield and neuroprotective potential.
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  Data: <searchLink fieldCode="AU" term="%22Ye+W%22">Ye W</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China; Key Laboratory of Functional Yeast of China National Light Industry, Hubei Key Laboratory of Natural Products Research and Development, Hubei Engineering Research Center for Bioenzyme Engineering Technology, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China.<br /><searchLink fieldCode="AU" term="%22Ye+W%22">Ye W</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519087, China.<br /><searchLink fieldCode="AU" term="%22She+W%22">She W</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Huang+D%22">Huang D</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Qin+D%22">Qin D</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Chik+SY%22">Chik SY</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Pan+B%22">Pan B</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.<br /><searchLink fieldCode="AU" term="%22Sung+HH%22">Sung HH</searchLink>; Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Xu+B%22">Xu B</searchLink>; Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519087, China.<br /><searchLink fieldCode="AU" term="%22Williams+ID%22">Williams ID</searchLink>; Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Cheng+A%22">Cheng A</searchLink>; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macao Special Administrative Region, 999078, China; Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macao Special Administrative Region, 999078, China. Electronic address: chengaf@um.edu.mo.<br /><searchLink fieldCode="AU" term="%22Qian+P%22">Qian P</searchLink>; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Hong Kong 999077, China. Electronic address: boqianpy@ust.hk.
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  Data: <searchLink fieldCode="JN" term="%22101546952%22">Journal of advanced research</searchLink> [J Adv Res] 2026 Jun; Vol. 84, pp. 203-215. <i>Date of Electronic Publication: </i>2025 Sep 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cairo+University%2C+production+and+hosting+by+Elsevier+B%2E+V%22">Cairo University, production and hosting by Elsevier B. V </searchLink><i>Country of Publication: </i>Egypt <i>NLM ID: </i>101546952 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2090-1224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220901224%22">20901224 </searchLink><i>NLM ISO Abbreviation: </i>J Adv Res <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.jare.2025.08.064
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      – Code: eng
        Text: English
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              Text: 2026 Jun
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