View in EDS

Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial.

Saved in:
Bibliographic Details
Title: Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial.
Authors: Wick W; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany. wolfgang.wick@med.uni-heidelberg.de., Lanz LM; NCT Trial Center, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany., Wick A; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany., Harting I; Neuroradiology, University Clinic Heidelberg, Heidelberg University, Heidelberg, Germany., Dettmer S; NCT Trial Center, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany., Suwala AK; Neuropathology, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany., Ketter R; Neurosurgery, Saarland University, Homburg, Germany., Tabatabai G; Department of Neurology & Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tübingen, Germany.; Centre for Neuro-Oncology, Comprehensive Cancer Center Tübingen-Stuttgart, Tübingen, Germany., Seliger C; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany.; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany., Glas M; Division of Clinical Neurooncology, Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany., Burger MC; Dr. Senckenberg Institute of Neurooncology, Goethe University Frankfurt and Goethe University Hospital, Frankfurt, Germany., Timmer M; Department of Neurosurgery, University Hospital Cologne, Cologne, Germany., Ringel FA; Neurosurgery, University Medicine Mainz, Mainz, Germany.; Neurosurgery Clinic, Ludwig Maximilians University (LMU), Munich, Germany., Mildenberger I; German Cancer Consortium (DKTK) & CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center Heidelberg, Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience (MCTN), Heidelberg University & DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany., Schulz-Schaeffer WJ; Neuropathology, Saarland University, Homburg, Germany., Winkler F; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany., König L; Department of Radiation Oncology, University Clinic Heidelberg, Heidelberg University, Heidelberg, Germany., Herold-Mende C; Division of Experimental Neurosurgery, Neurosurgery Clinic, University Clinic Heidelberg, Heidelberg University, Heidelberg, Germany., Eisenmenger A; NCT Trial Center, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg University Hospital, Department of Pediatric Hematology and Oncology, National Center for Tumor Dieseases (NCT), Heidelberg, Germany., Renovanz M; Department of Neurology & Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tübingen, Germany.; Centre for Neuro-Oncology, Comprehensive Cancer Center Tübingen-Stuttgart, Tübingen, Germany.; Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany., Bendszus M; Neuroradiology, University Clinic Heidelberg, Heidelberg University, Heidelberg, Germany., Sahm F; Neuropathology, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de., Platten M; German Cancer Consortium (DKTK) & CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center Heidelberg, Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience (MCTN), Heidelberg University & DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany., Kessler T; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany.
Source: Nature medicine [Nat Med] 2025 Oct; Vol. 31 (10), pp. 3534-3541. Date of Electronic Publication: 2025 Sep 05.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40913172
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N<superscript>2</superscript>M<superscript>2</superscript> umbrella trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Wick+W%22">Wick W</searchLink>; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany. wolfgang.wick@med.uni-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Lanz+LM%22">Lanz LM</searchLink>; NCT Trial Center, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wick+A%22">Wick A</searchLink>; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Harting+I%22">Harting I</searchLink>; Neuroradiology, University Clinic Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dettmer+S%22">Dettmer S</searchLink>; NCT Trial Center, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Suwala+AK%22">Suwala AK</searchLink>; Neuropathology, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ketter+R%22">Ketter R</searchLink>; Neurosurgery, Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Tabatabai+G%22">Tabatabai G</searchLink>; Department of Neurology & Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tübingen, Germany.; Centre for Neuro-Oncology, Comprehensive Cancer Center Tübingen-Stuttgart, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Seliger+C%22">Seliger C</searchLink>; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany.; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Glas+M%22">Glas M</searchLink>; Division of Clinical Neurooncology, Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Burger+MC%22">Burger MC</searchLink>; Dr. Senckenberg Institute of Neurooncology, Goethe University Frankfurt and Goethe University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Timmer+M%22">Timmer M</searchLink>; Department of Neurosurgery, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ringel+FA%22">Ringel FA</searchLink>; Neurosurgery, University Medicine Mainz, Mainz, Germany.; Neurosurgery Clinic, Ludwig Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mildenberger+I%22">Mildenberger I</searchLink>; German Cancer Consortium (DKTK) & CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center Heidelberg, Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience (MCTN), Heidelberg University & DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Schulz-Schaeffer+WJ%22">Schulz-Schaeffer WJ</searchLink>; Neuropathology, Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Winkler+F%22">Winkler F</searchLink>; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22König+L%22">König L</searchLink>; Department of Radiation Oncology, University Clinic Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Herold-Mende+C%22">Herold-Mende C</searchLink>; Division of Experimental Neurosurgery, Neurosurgery Clinic, University Clinic Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Eisenmenger+A%22">Eisenmenger A</searchLink>; NCT Trial Center, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg University Hospital, Department of Pediatric Hematology and Oncology, National Center for Tumor Dieseases (NCT), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Renovanz+M%22">Renovanz M</searchLink>; Department of Neurology & Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tübingen, Germany.; Centre for Neuro-Oncology, Comprehensive Cancer Center Tübingen-Stuttgart, Tübingen, Germany.; Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Bendszus+M%22">Bendszus M</searchLink>; Neuroradiology, University Clinic Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sahm+F%22">Sahm F</searchLink>; Neuropathology, University Clinic Heidelberg, Heidelberg University & German Cancer Research Center, Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Platten+M%22">Platten M</searchLink>; German Cancer Consortium (DKTK) & CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center Heidelberg, Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience (MCTN), Heidelberg University & DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Kessler+T%22">Kessler T</searchLink>; Neurology, University Clinic Heidelberg, Heidelberg University & German Cancer Consortium (DKTK) and CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2025 Oct; Vol. 31 (10), pp. 3534-3541. <i>Date of Electronic Publication: </i>2025 Sep 05.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Company%22">Nature Publishing Company </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502015 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-170X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210788956%22">10788956 </searchLink><i>NLM ISO Abbreviation: </i>Nat Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40913172
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41591-025-03928-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 3534
    Titles:
      – TitleFull: Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wick W
      – PersonEntity:
          Name:
            NameFull: Lanz LM
      – PersonEntity:
          Name:
            NameFull: Wick A
      – PersonEntity:
          Name:
            NameFull: Harting I
      – PersonEntity:
          Name:
            NameFull: Dettmer S
      – PersonEntity:
          Name:
            NameFull: Suwala AK
      – PersonEntity:
          Name:
            NameFull: Ketter R
      – PersonEntity:
          Name:
            NameFull: Tabatabai G
      – PersonEntity:
          Name:
            NameFull: Seliger C
      – PersonEntity:
          Name:
            NameFull: Glas M
      – PersonEntity:
          Name:
            NameFull: Burger MC
      – PersonEntity:
          Name:
            NameFull: Timmer M
      – PersonEntity:
          Name:
            NameFull: Ringel FA
      – PersonEntity:
          Name:
            NameFull: Mildenberger I
      – PersonEntity:
          Name:
            NameFull: Schulz-Schaeffer WJ
      – PersonEntity:
          Name:
            NameFull: Winkler F
      – PersonEntity:
          Name:
            NameFull: König L
      – PersonEntity:
          Name:
            NameFull: Herold-Mende C
      – PersonEntity:
          Name:
            NameFull: Eisenmenger A
      – PersonEntity:
          Name:
            NameFull: Pfister SM
      – PersonEntity:
          Name:
            NameFull: Renovanz M
      – PersonEntity:
          Name:
            NameFull: Bendszus M
      – PersonEntity:
          Name:
            NameFull: Sahm F
      – PersonEntity:
          Name:
            NameFull: Platten M
      – PersonEntity:
          Name:
            NameFull: Kessler T
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: 2025 Oct
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1546-170X
          Numbering:
            – Type: volume
              Value: 31
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: Nature medicine
              Type: main
ResultId 1