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Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors.

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Title: Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors.
Authors: Brea EJ; Dana-Farber Cancer Institute, Boston, Massachusetts., Baldacci S; Dana-Farber Cancer Institute, Boston, Massachusetts., Savage N; Dana-Farber Cancer Institute, Boston, Massachusetts., Facchinetti F; Dana-Farber Cancer Institute, Boston, Massachusetts., Hinchey C; Dana-Farber Cancer Institute, Boston, Massachusetts., Chakravarti S; Dana-Farber Cancer Institute, Boston, Massachusetts., Mottram A; Dana-Farber Cancer Institute, Boston, Massachusetts., Ngo K; Dana-Farber Cancer Institute, Boston, Massachusetts., Vo H; Dana-Farber Cancer Institute, Boston, Massachusetts., Leeper BA; Dana-Farber Cancer Institute, Boston, Massachusetts., Tuladhar B; Dana-Farber Cancer Institute, Boston, Massachusetts., Ganapathy S; Dana-Farber Cancer Institute, Boston, Massachusetts., Ivanova EV; Dana-Farber Cancer Institute, Boston, Massachusetts., Saldanha A; Dana-Farber Cancer Institute, Boston, Massachusetts., Locquet MA; Dana-Farber Cancer Institute, Boston, Massachusetts., Salamah A; Dana-Farber Cancer Institute, Boston, Massachusetts., Holterhus M; Dana-Farber Cancer Institute, Boston, Massachusetts., Mesler EB; Dana-Farber Cancer Institute, Boston, Massachusetts., De Vizio M; Dana-Farber Cancer Institute, Boston, Massachusetts., Stornante C; Dana-Farber Cancer Institute, Boston, Massachusetts., Campisi M; Dana-Farber Cancer Institute, Boston, Massachusetts., Mahadevan NR; Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Thai TC; Dana-Farber Cancer Institute, Boston, Massachusetts., Haggerty TJ; Dana-Farber Cancer Institute, Boston, Massachusetts., Li Z; Dana-Farber Cancer Institute, Boston, Massachusetts., Nie C; Nona Biosciences, Natick, Massachusetts., Deng C; Nona Biosciences, Natick, Massachusetts., Wang X; Nona Biosciences, Natick, Massachusetts., Liu LL; Nona Biosciences, Natick, Massachusetts., Barbie TU; Dana-Farber Cancer Institute, Boston, Massachusetts., Gokhale PC; Dana-Farber Cancer Institute, Boston, Massachusetts., Paweletz CP; Dana-Farber Cancer Institute, Boston, Massachusetts., Ramasubramanian A; Dana-Farber Cancer Institute, Boston, Massachusetts., Jänne PA; Dana-Farber Cancer Institute, Boston, Massachusetts., Barbie DA; Dana-Farber Cancer Institute, Boston, Massachusetts.; Parker Institute for Cancer Immunotherapy, Dana-Farber Cancer Institute, Boston, Massachusetts., Smith EL; Dana-Farber Cancer Institute, Boston, Massachusetts.; Parker Institute for Cancer Immunotherapy, Dana-Farber Cancer Institute, Boston, Massachusetts.
Source: Cancer immunology research [Cancer Immunol Res] 2025 Nov 03; Vol. 13 (11), pp. 1749-1763.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE
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