Involvement of impaired phosphate production and aberrant extracellular ATP signaling in the pathogenesis of hypophosphatasia: Analysis of ALPL-Knockout human iPS cell models.

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Title: Involvement of impaired phosphate production and aberrant extracellular ATP signaling in the pathogenesis of hypophosphatasia: Analysis of ALPL-Knockout human iPS cell models.
Authors: Yamazaki M; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan., Ueta A; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan; 1st Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Suita, Osaka, 565-0871, Japan., Nakanishi T; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan., Tachikawa K; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan., Kawai M; Department of Molecular Genetics and Endocrinology, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan., Ozono K; Center for Promoting Treatment of Intractable Diseases, Iseikai International General Hospital, Osaka, Osaka, 530-0052, Japan., Michigami T; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan. Electronic address: michigami@wch.opho.jp.
Source: Bone [Bone] 2025 Dec; Vol. 201, pp. 117629. Date of Electronic Publication: 2025 Sep 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Involvement of impaired phosphate production and aberrant extracellular ATP signaling in the pathogenesis of hypophosphatasia: Analysis of ALPL-Knockout human iPS cell models.
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  Data: <searchLink fieldCode="AU" term="%22Yamazaki+M%22">Yamazaki M</searchLink>; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan.<br /><searchLink fieldCode="AU" term="%22Ueta+A%22">Ueta A</searchLink>; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan; 1st Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Nakanishi+T%22">Nakanishi T</searchLink>; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan.<br /><searchLink fieldCode="AU" term="%22Tachikawa+K%22">Tachikawa K</searchLink>; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan.<br /><searchLink fieldCode="AU" term="%22Kawai+M%22">Kawai M</searchLink>; Department of Molecular Genetics and Endocrinology, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan.<br /><searchLink fieldCode="AU" term="%22Ozono+K%22">Ozono K</searchLink>; Center for Promoting Treatment of Intractable Diseases, Iseikai International General Hospital, Osaka, Osaka, 530-0052, Japan.<br /><searchLink fieldCode="AU" term="%22Michigami+T%22">Michigami T</searchLink>; Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka, 594-1101, Japan. Electronic address: michigami@wch.opho.jp.
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  Data: <searchLink fieldCode="JN" term="%228504048%22">Bone</searchLink> [Bone] 2025 Dec; Vol. 201, pp. 117629. <i>Date of Electronic Publication: </i>2025 Sep 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8504048 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2763 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218732763%22">18732763 </searchLink><i>NLM ISO Abbreviation: </i>Bone <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bone.2025.117629
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        Text: English
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      – TitleFull: Involvement of impaired phosphate production and aberrant extracellular ATP signaling in the pathogenesis of hypophosphatasia: Analysis of ALPL-Knockout human iPS cell models.
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              Text: 2025 Dec
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