PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer.
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| Title: | PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer. |
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| Authors: | Knox JJ; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., O'Kane G; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., King D; Northwell Health Cancer Institute, Lake Success, NY., Laheru D; Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine, Baltimore, MD., Habowski AN; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY., Yu K; Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY., Perez K; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA., Aguirre AJ; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA., Coyne Z; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Harvey H; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., McLaughlin RA; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Jang RW; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Grant RC; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Elimova EC; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Renouf DJ; BC Cancer, Vancouver, BC, Canada., Fischer S; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Duan K; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Ramotar S; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Jang GH; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Zhang A; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Devoe CE; Northwell Health Cancer Institute, Lake Success, NY., Singh H; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA., Pishvaian MJ; NCR Kimmel Cancer Center, Sibley Memorial Hospital and Johns Hopkins University School of Medicine, Washington, DC., Froeling FEM; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY., Saif MW; Northwell Health Cancer Institute, Lake Success, NY., O'Reilly EM; Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY., Tsang ES; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Wolpin BM; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA., Wilson JM; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Dodd A; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Pugh TJ; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Ye XY; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Gallinger S; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Tuveson DA; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY., Notta F; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada., Jaffee EM; Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine, Baltimore, MD. |
| Source: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2025 Nov; Vol. 43 (31), pp. 3355-3368. Date of Electronic Publication: 2025 Sep 10. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40929627 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Knox+JJ%22">Knox JJ</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22O'Kane+G%22">O'Kane G</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22King+D%22">King D</searchLink>; Northwell Health Cancer Institute, Lake Success, NY.<br /><searchLink fieldCode="AU" term="%22Laheru+D%22">Laheru D</searchLink>; Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Habowski+AN%22">Habowski AN</searchLink>; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.<br /><searchLink fieldCode="AU" term="%22Yu+K%22">Yu K</searchLink>; Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.<br /><searchLink fieldCode="AU" term="%22Perez+K%22">Perez K</searchLink>; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Aguirre+AJ%22">Aguirre AJ</searchLink>; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Coyne+Z%22">Coyne Z</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Harvey+H%22">Harvey H</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22McLaughlin+RA%22">McLaughlin RA</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jang+RW%22">Jang RW</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Grant+RC%22">Grant RC</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Elimova+EC%22">Elimova EC</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Renouf+DJ%22">Renouf DJ</searchLink>; BC Cancer, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Fischer+S%22">Fischer S</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Duan+K%22">Duan K</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ramotar+S%22">Ramotar S</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jang+GH%22">Jang GH</searchLink>; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Devoe+CE%22">Devoe CE</searchLink>; Northwell Health Cancer Institute, Lake Success, NY.<br /><searchLink fieldCode="AU" term="%22Singh+H%22">Singh H</searchLink>; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Pishvaian+MJ%22">Pishvaian MJ</searchLink>; NCR Kimmel Cancer Center, Sibley Memorial Hospital and Johns Hopkins University School of Medicine, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Froeling+FEM%22">Froeling FEM</searchLink>; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.<br /><searchLink fieldCode="AU" term="%22Saif+MW%22">Saif MW</searchLink>; Northwell Health Cancer Institute, Lake Success, NY.<br /><searchLink fieldCode="AU" term="%22O'Reilly+EM%22">O'Reilly EM</searchLink>; Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.<br /><searchLink fieldCode="AU" term="%22Tsang+ES%22">Tsang ES</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wolpin+BM%22">Wolpin BM</searchLink>; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Wilson+JM%22">Wilson JM</searchLink>; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dodd+A%22">Dodd A</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pugh+TJ%22">Pugh TJ</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ye+XY%22">Ye XY</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gallinger+S%22">Gallinger S</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tuveson+DA%22">Tuveson DA</searchLink>; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.<br /><searchLink fieldCode="AU" term="%22Notta+F%22">Notta F</searchLink>; McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jaffee+EM%22">Jaffee EM</searchLink>; Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine, Baltimore, MD. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2025 Nov; Vol. 43 (31), pp. 3355-3368. <i>Date of Electronic Publication: </i>2025 Sep 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+of+Clinical+Oncology%22">American Society of Clinical Oncology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309333 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-7755 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220732183X%22">0732183X </searchLink><i>NLM ISO Abbreviation: </i>J Clin Oncol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40929627 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1200/JCO-25-00436 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 3355 Titles: – TitleFull: PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Knox JJ – PersonEntity: Name: NameFull: O'Kane G – PersonEntity: Name: NameFull: King D – PersonEntity: Name: NameFull: Laheru D – PersonEntity: Name: NameFull: Habowski AN – PersonEntity: Name: NameFull: Yu K – PersonEntity: Name: NameFull: Perez K – PersonEntity: Name: NameFull: Aguirre AJ – PersonEntity: Name: NameFull: Coyne Z – PersonEntity: Name: NameFull: Harvey H – PersonEntity: Name: NameFull: McLaughlin RA – PersonEntity: Name: NameFull: Jang RW – PersonEntity: Name: NameFull: Grant RC – PersonEntity: Name: NameFull: Elimova EC – PersonEntity: Name: NameFull: Renouf DJ – PersonEntity: Name: NameFull: Fischer S – PersonEntity: Name: NameFull: Duan K – PersonEntity: Name: NameFull: Ramotar S – PersonEntity: Name: NameFull: Jang GH – PersonEntity: Name: NameFull: Zhang A – PersonEntity: Name: NameFull: Devoe CE – PersonEntity: Name: NameFull: Singh H – PersonEntity: Name: NameFull: Pishvaian MJ – PersonEntity: Name: NameFull: Froeling FEM – PersonEntity: Name: NameFull: Saif MW – PersonEntity: Name: NameFull: O'Reilly EM – PersonEntity: Name: NameFull: Tsang ES – PersonEntity: Name: NameFull: Wolpin BM – PersonEntity: Name: NameFull: Wilson JM – PersonEntity: Name: NameFull: Dodd A – PersonEntity: Name: NameFull: Pugh TJ – PersonEntity: Name: NameFull: Ye XY – PersonEntity: Name: NameFull: Gallinger S – PersonEntity: Name: NameFull: Tuveson DA – PersonEntity: Name: NameFull: Notta F – PersonEntity: Name: NameFull: Jaffee EM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: 2025 Nov Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1527-7755 Numbering: – Type: volume Value: 43 – Type: issue Value: 31 Titles: – TitleFull: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Type: main |
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