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Blood transcriptomic analysis reveals a distinct molecular subtype of treatment resistant depression compared to non-treatment resistant depression.

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Title: Blood transcriptomic analysis reveals a distinct molecular subtype of treatment resistant depression compared to non-treatment resistant depression.
Authors: Sirés A; Hospital del Mar Research Institute (HMRIB), Barcelona, Spain., Domínguez-Barragán J; Hospital del Mar Research Institute (HMRIB), Barcelona, Spain., Lorenzon N; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain; Biomedical Research Networking Center for Rare Diseases (CIBERER), Barcelona 08003, Spain., Meskini O; Paris Brain Institute (ICM), National Centre for Scientific Research (CNRS), Paris, France., Buson L; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Silva RC; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Bortolomasi M; Psychiatric Hospital 'Villa Santa Chiara', Verona, Italy., Perusi G; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Menesello V; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Gennarelli M; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Carpiniello B; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy., Ferensztaj-Rochowiak E; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland., Rybakowski F; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland., Sanz F; Hospital del Mar Research Institute (HMRIB), Barcelona, Spain; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain., Pisanu C; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Squassina A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Manchia M; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Dierssen M; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; Biomedical Research Networking Center for Rare Diseases (CIBERER), Barcelona 08003, Spain., Baune BT; Department of Psychiatry, University of Münster, Münster, Germany; Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia., Minelli A; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. Electronic address: alessandra.minelli@unibs.it., Potier MC; Paris Brain Institute (ICM), National Centre for Scientific Research (CNRS), Paris, France. Electronic address: marie-claude.potier@icm-institute.org., Perera-Bel J; Hospital del Mar Research Institute (HMRIB), Barcelona, Spain; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: jperera@researchmar.net.
Corporate Authors: PROMPT Study Group
Source: Brain, behavior, and immunity [Brain Behav Immun] 2025 Nov; Vol. 130, pp. 106103. Date of Electronic Publication: 2025 Sep 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
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  Data: Blood transcriptomic analysis reveals a distinct molecular subtype of treatment resistant depression compared to non-treatment resistant depression.
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  Data: <searchLink fieldCode="AU" term="%22Sirés+A%22">Sirés A</searchLink>; Hospital del Mar Research Institute (HMRIB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Domínguez-Barragán+J%22">Domínguez-Barragán J</searchLink>; Hospital del Mar Research Institute (HMRIB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lorenzon+N%22">Lorenzon N</searchLink>; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain; Biomedical Research Networking Center for Rare Diseases (CIBERER), Barcelona 08003, Spain.<br /><searchLink fieldCode="AU" term="%22Meskini+O%22">Meskini O</searchLink>; Paris Brain Institute (ICM), National Centre for Scientific Research (CNRS), Paris, France.<br /><searchLink fieldCode="AU" term="%22Buson+L%22">Buson L</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Silva+RC%22">Silva RC</searchLink>; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bortolomasi+M%22">Bortolomasi M</searchLink>; Psychiatric Hospital 'Villa Santa Chiara', Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Perusi+G%22">Perusi G</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Menesello+V%22">Menesello V</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Gennarelli+M%22">Gennarelli M</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Carpiniello+B%22">Carpiniello B</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Ferensztaj-Rochowiak+E%22">Ferensztaj-Rochowiak E</searchLink>; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.<br /><searchLink fieldCode="AU" term="%22Rybakowski+F%22">Rybakowski F</searchLink>; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.<br /><searchLink fieldCode="AU" term="%22Sanz+F%22">Sanz F</searchLink>; Hospital del Mar Research Institute (HMRIB), Barcelona, Spain; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pisanu+C%22">Pisanu C</searchLink>; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Squassina+A%22">Squassina A</searchLink>; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Manchia+M%22">Manchia M</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Dierssen+M%22">Dierssen M</searchLink>; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; Biomedical Research Networking Center for Rare Diseases (CIBERER), Barcelona 08003, Spain.<br /><searchLink fieldCode="AU" term="%22Baune+BT%22">Baune BT</searchLink>; Department of Psychiatry, University of Münster, Münster, Germany; Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Minelli+A%22">Minelli A</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. Electronic address: alessandra.minelli@unibs.it.<br /><searchLink fieldCode="AU" term="%22Potier+MC%22">Potier MC</searchLink>; Paris Brain Institute (ICM), National Centre for Scientific Research (CNRS), Paris, France. Electronic address: marie-claude.potier@icm-institute.org.<br /><searchLink fieldCode="AU" term="%22Perera-Bel+J%22">Perera-Bel J</searchLink>; Hospital del Mar Research Institute (HMRIB), Barcelona, Spain; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: jperera@researchmar.net.
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