Molecular analysis of lung adenocarcinomas from the SAFIR02-Lung cohort reveals new metastasis-associated copy-number alterations including frequent mutant-specific KRAS-allelic imbalance and identifies CDKN2A homozygous deletions as an independent biomarker of poor prognosis.
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| Title: | Molecular analysis of lung adenocarcinomas from the SAFIR02-Lung cohort reveals new metastasis-associated copy-number alterations including frequent mutant-specific KRAS-allelic imbalance and identifies CDKN2A homozygous deletions as an independent biomarker of poor prognosis. |
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| Authors: | Hamza A; Department of Genetics, Institut Curie, PSL Research University, Paris, France.; INSERM U1016, Paris Cité University, Faculty of Pharmaceutical and Biological Sciences, Paris, France., Gestraud P; Computational Oncology, PSL Research University, Mines Paris Tech, INSERM U91331, Paris, France., Karimi M; Service de Biostatistique et d'Épidémiologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France.; Oncostat U1018, Inserm, Université Paris-Saclay, Équipe Labellisée Ligue Contre le Cancer, Villejuif, France., Tran-Dien A; Bioinformatics Platform, Gustave Roussy, Villejuif, France., Syx L; Computational Oncology, PSL Research University, Mines Paris Tech, INSERM U91331, Paris, France., Vacher S; Department of Genetics, Institut Curie, PSL Research University, Paris, France., Peretti Q; Department of Genetics, Institut Curie, PSL Research University, Paris, France., Lacroix L; Department of Medical Biology and Pathology, Gustave Roussy, Villejuif, France., Attignon V; Cancer Genomic Platform, Centre Léon Bérard, Lyon, France., Soubeyran I; Department of Biopathology, Institut Bergonié, Bordeaux, France., Jézéquel P; Omics and Data Science Unit, Institut de Cancérologie de l'Ouest (ICO), Angers-Nantes, France., Planchard D; Department of Medical Oncology, Gustave Roussy, Villejuif, France.; Paris Saclay University, Kremlin-Bicêtre, France., Melaabi S; Department of Genetics, Institut Curie, PSL Research University, Paris, France., Dailey-Chwalibóg T; Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.; Agence de Formation de Recherche et d'Expertise en Santé pour l'Afrique (AFRICSanté), Bobo-Dioulsso, Burkina Faso., Jimenez M; R&D Unicancer, Paris, France., Michiels S; Service de Biostatistique et d'Épidémiologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France.; Oncostat U1018, Inserm, Université Paris-Saclay, Équipe Labellisée Ligue Contre le Cancer, Villejuif, France., Servant N; Computational Oncology, PSL Research University, Mines Paris Tech, INSERM U91331, Paris, France., Le Tourneau C; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France., Girard N; Thorax Institute Curie Montsouris, Department of Medical Oncology, Institut Curie, Paris, France., André F; Department of Medical Oncology, Gustave Roussy, Villejuif, France.; Gustave Roussy Cancer Campus, PRISM-PRecISion Medicine Center in Oncology, Villejuif, France.; Paris Saclay University, Kremlin-Bicêtre, France., Besse B; Department of Medical Oncology, Gustave Roussy, Villejuif, France., Kamal M; Department of Medical Oncology, Gustave Roussy, Villejuif, France.; Gustave Roussy Cancer Campus, PRISM-PRecISion Medicine Center in Oncology, Villejuif, France.; Paris Saclay University, Kremlin-Bicêtre, France., Barlesi F; Department of Medical Oncology, Gustave Roussy, Villejuif, France.; Paris Saclay University, Kremlin-Bicêtre, France., Bièche I; Department of Genetics, Institut Curie, PSL Research University, Paris, France. ivan.bieche@curie.fr.; INSERM U1016, Paris Cité University, Faculty of Pharmaceutical and Biological Sciences, Paris, France. ivan.bieche@curie.fr. |
| Source: | British journal of cancer [Br J Cancer] 2025 Nov; Vol. 133 (10), pp. 1554-1564. Date of Electronic Publication: 2025 Sep 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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