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Varying Levels of Inflammatory Activity in Brain and Body of Patients with Persistent Fatigue and Difficulty Concentrating After COVID-19: A TSPO PET Study.

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Title: Varying Levels of Inflammatory Activity in Brain and Body of Patients with Persistent Fatigue and Difficulty Concentrating After COVID-19: A TSPO PET Study.
Authors: Visser D; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands; d.visser2@amsterdamumc.nl.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Golla SSV; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., Palard-Novello X; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; University of Rennes, Rennes, France., Verfaillie SCJ; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; GGz inGeest Specialized Mental Health Care, Amsterdam, The Netherlands., Verveen A; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Koch DW; Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands., Rikken RM; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., van de Giessen E; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., Nieuwkerk PT; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., den Hollander ME; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., Horn J; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands., van Heugten CM; Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands., de Jong MD; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam, The Netherlands., van den Wijngaard CC; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., van der Maaden T; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., van Os YMG; Occupational Health Office, Department of Human Resources, University Medical Center Utrecht, Utrecht, The Netherlands., Prins M; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands., Visser-Meily JMA; Department of Rehabilitation, Physical Therapy Science and Sports, University Medical Center Utrecht, Utrecht, The Netherlands., Schober P; Department of Anaesthesiology, Amsterdam UMC, Amsterdam, The Netherlands., Schuit RC; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., Kassiou M; School of Chemistry, University of Sydney, Sydney, New South Wales, Australia., Windhorst AD; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., Biere-Rafi S; Family Medicine, Amsterdam, The Netherlands., Appelman B; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, The Netherlands; and., van Vugt M; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands., Barkhof F; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; Institute of Neurology and Healthcare Engineering, University College London, London, United Kingdom., van Berckel BNM; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., Boellaard R; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., Knoop H; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Tolboom N; Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2025 Nov 03; Vol. 66 (11), pp. 1787-1794. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Varying Levels of Inflammatory Activity in Brain and Body of Patients with Persistent Fatigue and Difficulty Concentrating After COVID-19: A TSPO PET Study.
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  Data: <searchLink fieldCode="AU" term="%22Visser+D%22">Visser D</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands; d.visser2@amsterdamumc.nl.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Golla+SSV%22">Golla SSV</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Palard-Novello+X%22">Palard-Novello X</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; University of Rennes, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Verfaillie+SCJ%22">Verfaillie SCJ</searchLink>; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; GGz inGeest Specialized Mental Health Care, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Verveen+A%22">Verveen A</searchLink>; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Koch+DW%22">Koch DW</searchLink>; Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rikken+RM%22">Rikken RM</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Giessen+E%22">van de Giessen E</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nieuwkerk+PT%22">Nieuwkerk PT</searchLink>; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22den+Hollander+ME%22">den Hollander ME</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Horn+J%22">Horn J</searchLink>; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Heugten+CM%22">van Heugten CM</searchLink>; Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Jong+MD%22">de Jong MD</searchLink>; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Wijngaard+CC%22">van den Wijngaard CC</searchLink>; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Maaden+T%22">van der Maaden T</searchLink>; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Os+YMG%22">van Os YMG</searchLink>; Occupational Health Office, Department of Human Resources, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Prins+M%22">Prins M</searchLink>; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Visser-Meily+JMA%22">Visser-Meily JMA</searchLink>; Department of Rehabilitation, Physical Therapy Science and Sports, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schober+P%22">Schober P</searchLink>; Department of Anaesthesiology, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schuit+RC%22">Schuit RC</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kassiou+M%22">Kassiou M</searchLink>; School of Chemistry, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Windhorst+AD%22">Windhorst AD</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Biere-Rafi+S%22">Biere-Rafi S</searchLink>; Family Medicine, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Appelman+B%22">Appelman B</searchLink>; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, The Netherlands; and.<br /><searchLink fieldCode="AU" term="%22van+Vugt+M%22">van Vugt M</searchLink>; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Barkhof+F%22">Barkhof F</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.; Institute of Neurology and Healthcare Engineering, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22van+Berckel+BNM%22">van Berckel BNM</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Boellaard+R%22">Boellaard R</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Brain Imaging, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Knoop+H%22">Knoop H</searchLink>; Department of Medical Psychology, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tolboom+N%22">Tolboom N</searchLink>; Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
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