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Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice.

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Title: Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice.
Authors: Trautman ME; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Nutrition and Metabolism Graduate Program, University of Wisconsin-Madison, Madison, WI, USA., Green CL; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA., MacArthur MR; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08540, USA., Chaiyakul K; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WI 53705, USA., Alam YH; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Yeh CY; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA., Babygirija R; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Cell and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA., James I; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Gilpin M; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Zelenovskiy E; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA., Green M; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA., Marshall RN; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA., Raskin A; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA., Sonsalla MM; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706, USA., Flores V; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Nutrition and Metabolism Graduate Program, University of Wisconsin-Madison, Madison, WI, USA., Simcox JA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706, USA; Wisconsin Nathan Shock Center of Excellence in the Biology of Aging, Madison, WI 53705, USA., Ong IM; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WI 53705, USA., Malecki KC; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA., Jang C; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Lamming DW; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Nutrition and Metabolism Graduate Program, University of Wisconsin-Madison, Madison, WI, USA; Cell and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Nathan Shock Center of Excellence in the Biology of Aging, Madison, WI 53705, USA; Comparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, WI, USA; University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53705, USA; University of Wisconsin-Madison Comprehensive Diabetes Center, Madison, WI 53705, USA. Electronic address: dlamming@medicine.wisc.edu.
Source: Molecular metabolism [Mol Metab] 2025 Nov; Vol. 101, pp. 102248. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
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  Data: Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice.
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  Data: <searchLink fieldCode="AU" term="%22Trautman+ME%22">Trautman ME</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Nutrition and Metabolism Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Green+CL%22">Green CL</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22MacArthur+MR%22">MacArthur MR</searchLink>; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.<br /><searchLink fieldCode="AU" term="%22Chaiyakul+K%22">Chaiyakul K</searchLink>; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Alam+YH%22">Alam YH</searchLink>; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.<br /><searchLink fieldCode="AU" term="%22Yeh+CY%22">Yeh CY</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Babygirija+R%22">Babygirija R</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Cell and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22James+I%22">James I</searchLink>; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Gilpin+M%22">Gilpin M</searchLink>; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Zelenovskiy+E%22">Zelenovskiy E</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Green+M%22">Green M</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Marshall+RN%22">Marshall RN</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Raskin+A%22">Raskin A</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Sonsalla+MM%22">Sonsalla MM</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706, USA.<br /><searchLink fieldCode="AU" term="%22Flores+V%22">Flores V</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Nutrition and Metabolism Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Simcox+JA%22">Simcox JA</searchLink>; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706, USA; Wisconsin Nathan Shock Center of Excellence in the Biology of Aging, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Ong+IM%22">Ong IM</searchLink>; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Malecki+KC%22">Malecki KC</searchLink>; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA.<br /><searchLink fieldCode="AU" term="%22Jang+C%22">Jang C</searchLink>; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.<br /><searchLink fieldCode="AU" term="%22Lamming+DW%22">Lamming DW</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Nutrition and Metabolism Graduate Program, University of Wisconsin-Madison, Madison, WI, USA; Cell and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Nathan Shock Center of Excellence in the Biology of Aging, Madison, WI 53705, USA; Comparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, WI, USA; University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53705, USA; University of Wisconsin-Madison Comprehensive Diabetes Center, Madison, WI 53705, USA. Electronic address: dlamming@medicine.wisc.edu.
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