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The use of bone-modifying agents in early breast cancer: AIOM Guidelines update and perspectives.

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Title: The use of bone-modifying agents in early breast cancer: AIOM Guidelines update and perspectives.
Authors: Zambelli A; ASST Papa Giovanni XXIII UO Clinica Oncologia Medica, Bergamo, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Gerosa R; Humanitas Clinical and Research Center-IRCCS, Humanitas Cancer Center, Milan, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Pieve Emanuele, Italy., Cinquini M; Laboratory of Systematic Reviews Methodology and Guidelines Production, Clinical Oncology Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano Italy., Di Maio M; Department of Oncology, University of Turin, AOU Città della Salute e della Scienza di Torino, Turin, Italy., Miglietta F; Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Università di Padova, Padova, Italy.; Division of Oncology 2, Istituto Oncologico Veneto - IRCCS, Padova, Italy., Arecco L; Université libre de Bruxelles, Hôpital Universitaire de Bruxelles, Institut Jules Bordet, Academic Trials Promoting Team, Bruxelles, Belgium.; UOC Clinica Oncologia Medica, IRCSS Ospedale Policlinico San Martino, Genoa, Italy., Biganzoli L; Department of Oncology, Hospital of Prato Azienda USL Toscana Centro, Prato, Italy., Bernardi D; Humanitas Clinical and Research Center-IRCCS, Humanitas Cancer Center, Milan, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Pieve Emanuele, Italy., Cortesi L; Medical Oncology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy.; Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia., Del Mastro L; UOC Clinica Oncologia Medica, IRCSS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Internal Medicine and Medical Specialties, Università di Genova, Genoa, Italy., Dieci MV; Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Università di Padova, Padova, Italy.; Division of Oncology 2, Istituto Oncologico Veneto - IRCCS, Padova, Italy., Foglietta J; Medical and Translational Oncology, Santa Maria Hospital, Terni, Italy., Fortunato L; Breast Center, Azienda Ospedaliera San Giovanni-Addolorata, Rome, Italy., Franco P; Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.; Department of Radiation Oncology, 'Maggiore della Carità' University Hospital, Novara, Italy., Mantellini P; Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy., Marchiò C; Department of Medical Sciences, University of Turin, Turin, Italy.; Pathology Unit, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Meduri B; Department of Radiation Oncology, University Hospital of Modena, Modena, Italy., Micallo G; Oncologia, Istituto Tumori - Fondazione Pascale, Naples, Italy., Musolino A; Medical Oncology, Breast and GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori, 'Dino Amadori,' Meldola, Italy., Salvetti A; SIMG - Società Italiana della Medicina Generale e delle Cure Primarie, Italy., Santini D; Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, University of Rome, Sapienza Rome, Italy., Lanzetta G; Clinical Oncology Unit, Istituto Neurotraumatologico Italiano Grottaferrata, Rome, Italy., Cosentini D; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology Unit, University of Brescia, ASST Spedali Civili, Brescia, Italy., Bertoldo F; Internal Medicine, Metabolic Bone Diseases and Osteoncology Section, Department of Medicine, University of Verona, Verona, Italy.; Metabolic Bone Diseases and Osteoporosis Section Endocrinology Unit, Policlinico GB Rossi P.zza LA Scuro, Verona, Italy., Cazzato RL; Department of Interventional Radiology, University Hospital of Strasbourg, Strasbourg, France., Cellini F; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy.; Università Cattolica del Sacro Cuore, Dipartimento Universitario Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy., Denaro V; Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Di Martino A; Orthopedic Department, IRCCS-Istituto Ortopedico Rizzoli, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences - DIBINEM, University of Bologna, Italy., Fusco V; Oncology Unit and DAIRI - Department of Integration, Research and Innovation, Azienda Ospedaliero-Universitaria di Alessandria 'SS, Antonio e Biagio e Cesare Arrigo', Alessandria, Italy., Greco C; Department of Radiation Oncology, Università Campus Bio-Medico di Roma, Roma, Italy.; Department of Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Roma, Italy., Ibrahim T; Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Maccauro G; Orthopaedics and Traumatology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.; Orthopaedics and Traumatology Department, Università Cattolica del Sacro Cuore, Roma, Italy., DeFeo G; Supportive Care in Cancer Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Onco-Haematology, Milan, Italy., Severi S; Unit of Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori - IRST Dino Amadori, Meldola, Forlì-Cesena, Italy., Gori S; Medical Oncology, IRCCS-Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
Source: Tumori [Tumori] 2025 Oct; Vol. 111 (5), pp. 366-378. Date of Electronic Publication: 2025 Sep 15.
Publication Type: Editorial; Practice Guideline
Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 0111356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2038-2529 (Electronic) Linking ISSN: 03008916 NLM ISO Abbreviation: Tumori Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The use of bone-modifying agents in early breast cancer: AIOM Guidelines update and perspectives.
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  Data: <searchLink fieldCode="AU" term="%22Zambelli+A%22">Zambelli A</searchLink>; ASST Papa Giovanni XXIII UO Clinica Oncologia Medica, Bergamo, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Gerosa+R%22">Gerosa R</searchLink>; Humanitas Clinical and Research Center-IRCCS, Humanitas Cancer Center, Milan, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Pieve Emanuele, Italy.<br /><searchLink fieldCode="AU" term="%22Cinquini+M%22">Cinquini M</searchLink>; Laboratory of Systematic Reviews Methodology and Guidelines Production, Clinical Oncology Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano Italy.<br /><searchLink fieldCode="AU" term="%22Di+Maio+M%22">Di Maio M</searchLink>; Department of Oncology, University of Turin, AOU Città della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Miglietta+F%22">Miglietta F</searchLink>; Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Università di Padova, Padova, Italy.; Division of Oncology 2, Istituto Oncologico Veneto - IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Arecco+L%22">Arecco L</searchLink>; Université libre de Bruxelles, Hôpital Universitaire de Bruxelles, Institut Jules Bordet, Academic Trials Promoting Team, Bruxelles, Belgium.; UOC Clinica Oncologia Medica, IRCSS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Biganzoli+L%22">Biganzoli L</searchLink>; Department of Oncology, Hospital of Prato Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+D%22">Bernardi D</searchLink>; Humanitas Clinical and Research Center-IRCCS, Humanitas Cancer Center, Milan, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Pieve Emanuele, Italy.<br /><searchLink fieldCode="AU" term="%22Cortesi+L%22">Cortesi L</searchLink>; Medical Oncology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy.; Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia.<br /><searchLink fieldCode="AU" term="%22Del+Mastro+L%22">Del Mastro L</searchLink>; UOC Clinica Oncologia Medica, IRCSS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Internal Medicine and Medical Specialties, Università di Genova, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Dieci+MV%22">Dieci MV</searchLink>; Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Università di Padova, Padova, Italy.; Division of Oncology 2, Istituto Oncologico Veneto - IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Foglietta+J%22">Foglietta J</searchLink>; Medical and Translational Oncology, Santa Maria Hospital, Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Fortunato+L%22">Fortunato L</searchLink>; Breast Center, Azienda Ospedaliera San Giovanni-Addolorata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Franco+P%22">Franco P</searchLink>; Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.; Department of Radiation Oncology, 'Maggiore della Carità' University Hospital, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Mantellini+P%22">Mantellini P</searchLink>; Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Marchiò+C%22">Marchiò C</searchLink>; Department of Medical Sciences, University of Turin, Turin, Italy.; Pathology Unit, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Meduri+B%22">Meduri B</searchLink>; Department of Radiation Oncology, University Hospital of Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Micallo+G%22">Micallo G</searchLink>; Oncologia, Istituto Tumori - Fondazione Pascale, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Musolino+A%22">Musolino A</searchLink>; Medical Oncology, Breast and GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori, 'Dino Amadori,' Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Salvetti+A%22">Salvetti A</searchLink>; SIMG - Società Italiana della Medicina Generale e delle Cure Primarie, Italy.<br /><searchLink fieldCode="AU" term="%22Santini+D%22">Santini D</searchLink>; Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, University of Rome, Sapienza Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lanzetta+G%22">Lanzetta G</searchLink>; Clinical Oncology Unit, Istituto Neurotraumatologico Italiano Grottaferrata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cosentini+D%22">Cosentini D</searchLink>; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology Unit, University of Brescia, ASST Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bertoldo+F%22">Bertoldo F</searchLink>; Internal Medicine, Metabolic Bone Diseases and Osteoncology Section, Department of Medicine, University of Verona, Verona, Italy.; Metabolic Bone Diseases and Osteoporosis Section Endocrinology Unit, Policlinico GB Rossi P.zza LA Scuro, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Cazzato+RL%22">Cazzato RL</searchLink>; Department of Interventional Radiology, University Hospital of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Cellini+F%22">Cellini F</searchLink>; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy.; Università Cattolica del Sacro Cuore, Dipartimento Universitario Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Denaro+V%22">Denaro V</searchLink>; Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Martino+A%22">Di Martino A</searchLink>; Orthopedic Department, IRCCS-Istituto Ortopedico Rizzoli, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences - DIBINEM, University of Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Fusco+V%22">Fusco V</searchLink>; Oncology Unit and DAIRI - Department of Integration, Research and Innovation, Azienda Ospedaliero-Universitaria di Alessandria 'SS, Antonio e Biagio e Cesare Arrigo', Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Greco+C%22">Greco C</searchLink>; Department of Radiation Oncology, Università Campus Bio-Medico di Roma, Roma, Italy.; Department of Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Ibrahim+T%22">Ibrahim T</searchLink>; Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Maccauro+G%22">Maccauro G</searchLink>; Orthopaedics and Traumatology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.; Orthopaedics and Traumatology Department, Università Cattolica del Sacro Cuore, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22DeFeo+G%22">DeFeo G</searchLink>; Supportive Care in Cancer Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Onco-Haematology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Severi+S%22">Severi S</searchLink>; Unit of Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori - IRST Dino Amadori, Meldola, Forlì-Cesena, Italy.<br /><searchLink fieldCode="AU" term="%22Gori+S%22">Gori S</searchLink>; Medical Oncology, IRCCS-Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
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