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Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome.

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Title: Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome.
Authors: Lao P; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Edwards N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.; Department of Neuroscience, Columbia University, New York City, New York, USA., Flores-Aguilar L; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, California, USA., Alshikho MJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Smith A; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., LeMay R; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Hahm J; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Rizvi B; Department of Neurobiology & Behavior, University of California Irvine, Irvine, California, USA., Tudorascu D; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Rosas HD; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Radiology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA., Yassa M; Department of Neurobiology & Behavior, University of California Irvine, Irvine, California, USA.; Center for the Neurobiology of Learning and Memory, University of California, Irvine, California, USA., Christian B; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Mapstone M; Department of Neurology, University of California Irvine, Irvine, California, USA., Handen B; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Gutierrez J; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA., Wilcock D; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Head E; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, California, USA., Brickman AM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.
Corporate Authors: Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Sep; Vol. 21 (9), pp. e70679.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Lao+P%22">Lao P</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+N%22">Edwards N</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.; Department of Neuroscience, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Flores-Aguilar+L%22">Flores-Aguilar L</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Alshikho+MJ%22">Alshikho MJ</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Smith+A%22">Smith A</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22LeMay+R%22">LeMay R</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Hahm+J%22">Hahm J</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Rizvi+B%22">Rizvi B</searchLink>; Department of Neurobiology & Behavior, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Tudorascu+D%22">Tudorascu D</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Rosas+HD%22">Rosas HD</searchLink>; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Radiology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Yassa+M%22">Yassa M</searchLink>; Department of Neurobiology & Behavior, University of California Irvine, Irvine, California, USA.; Center for the Neurobiology of Learning and Memory, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Christian+B%22">Christian B</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Mapstone+M%22">Mapstone M</searchLink>; Department of Neurology, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Handen+B%22">Handen B</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Gutierrez+J%22">Gutierrez J</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wilcock+D%22">Wilcock D</searchLink>; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Brickman+AM%22">Brickman AM</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 Sep; Vol. 21 (9), pp. e70679.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.70679
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