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Synthesis and functional evaluation of tetrahydroisoquinoline and polysubstituted benzylamine derivatives as sigma-2 receptor-targeted small-molecule probes.

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Title: Synthesis and functional evaluation of tetrahydroisoquinoline and polysubstituted benzylamine derivatives as sigma-2 receptor-targeted small-molecule probes.
Authors: Chen AF; GuangDong Provincial Hospital of Chinese Medicine, Guang Zhou 510120, Guang Dong Province, China., Xie XY; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, School of Basic Medicine, Guizhou Medical University, Guiyang 550004, Gui Zhou Province, China., Xu WS; GuangDong Provincial Hospital of Chinese Medicine, Guang Zhou 510120, Guang Dong Province, China., Wang YX; GuangDong Provincial Hospital of Chinese Medicine, Guang Zhou 510120, Guang Dong Province, China., Liang HL; GuangDong Provincial Hospital of Chinese Medicine, Guang Zhou 510120, Guang Dong Province, China. Electronic address: 1577757087@qq.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Sep 13; Vol. 130, pp. 130403. Date of Electronic Publication: 2025 Sep 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40953681
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Synthesis and functional evaluation of tetrahydroisoquinoline and polysubstituted benzylamine derivatives as sigma-2 receptor-targeted small-molecule probes.
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  Data: <searchLink fieldCode="AU" term="%22Chen+AF%22">Chen AF</searchLink>; GuangDong Provincial Hospital of Chinese Medicine, Guang Zhou 510120, Guang Dong Province, China.<br /><searchLink fieldCode="AU" term="%22Xie+XY%22">Xie XY</searchLink>; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, School of Basic Medicine, Guizhou Medical University, Guiyang 550004, Gui Zhou Province, China.<br /><searchLink fieldCode="AU" term="%22Xu+WS%22">Xu WS</searchLink>; GuangDong Provincial Hospital of Chinese Medicine, Guang Zhou 510120, Guang Dong Province, China.<br /><searchLink fieldCode="AU" term="%22Wang+YX%22">Wang YX</searchLink>; GuangDong Provincial Hospital of Chinese Medicine, Guang Zhou 510120, Guang Dong Province, China.<br /><searchLink fieldCode="AU" term="%22Liang+HL%22">Liang HL</searchLink>; GuangDong Provincial Hospital of Chinese Medicine, Guang Zhou 510120, Guang Dong Province, China. Electronic address: 1577757087@qq.com.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2025 Sep 13; Vol. 130, pp. 130403. <i>Date of Electronic Publication: </i>2025 Sep 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bmcl.2025.130403
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      – Code: eng
        Text: English
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        StartPage: 130403
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            – D: 13
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              Text: 2025 Sep 13
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