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CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness.

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Title: CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness.
Authors: Romero-Moya D; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Torralba-Sales E; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Calvo C; Department of Physiological Sciences, Genetics Section, School Of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain.; Josep Carreras Leukaemia Research Institute, School of Medicine, University of Barcelona, Barcelona, Spain., Marin-Bejar O; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.; Germans Trias i Pujol Health Science Research Institute (IGTP), Cancer Program, Badalona, Catalonia, Spain., Magallon-Mosella M; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Distefano M; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain., Pera J; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Castaño J; Hospital Sant Joan de Deu Advanced Therapies Platform, SJD Pediatric Cancer Center Barcelona (PCCB) building, Barcelona, Spain., De Giorgio F; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Gonzalez J; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Josep Carreras Leukemia Research Institute (IJC), Badalona, Spain., Iglesias A; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Josep Carreras Leukemia Research Institute (IJC), Badalona, Spain., Berenguer-Balaguer C; Department of Medicine and Life Sciences, Endocrine Regulatory Genomics, Universitat Pompeu Fabra (UPF), Barcelona, Spain., Schilling M; Gene Regulation of Cell Identity Lab, Neurosciences Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain., Plass M; Gene Regulation of Cell Identity Lab, Neurosciences Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Spain.; Physiological Sciences Department, Faculty of Medicine and Health Sciences, University of Barcelona, L'Hospitalet del Llobregat, Spain., Pasquali L; Department of Medicine and Life Sciences, Endocrine Regulatory Genomics, Universitat Pompeu Fabra (UPF), Barcelona, Spain., Català A; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain.; Instituto de Salud Carlos III, Biomedical Network Research Centre on Rare Diseases, Madrid, Spain., Molina O; Department of Physiological Sciences, Genetics Section, School Of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain.; Josep Carreras Leukaemia Research Institute, School of Medicine, University of Barcelona, Barcelona, Spain., Wlodarski MW; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Bigas A; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Josep Carreras Leukemia Research Institute (IJC), Badalona, Spain., Giorgetti A; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain. agiorgetti@idibell.cat.; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Barcelona University, Barcelona, Spain. agiorgetti@idibell.cat.; Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain. agiorgetti@idibell.cat.
Source: Leukemia [Leukemia] 2025 Dec; Vol. 39 (12), pp. 3015-3025. Date of Electronic Publication: 2025 Sep 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness.
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  Data: <searchLink fieldCode="AU" term="%22Romero-Moya+D%22">Romero-Moya D</searchLink>; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Torralba-Sales+E%22">Torralba-Sales E</searchLink>; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Calvo+C%22">Calvo C</searchLink>; Department of Physiological Sciences, Genetics Section, School Of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain.; Josep Carreras Leukaemia Research Institute, School of Medicine, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Marin-Bejar+O%22">Marin-Bejar O</searchLink>; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.; Germans Trias i Pujol Health Science Research Institute (IGTP), Cancer Program, Badalona, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Magallon-Mosella+M%22">Magallon-Mosella M</searchLink>; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Distefano+M%22">Distefano M</searchLink>; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pera+J%22">Pera J</searchLink>; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Castaño+J%22">Castaño J</searchLink>; Hospital Sant Joan de Deu Advanced Therapies Platform, SJD Pediatric Cancer Center Barcelona (PCCB) building, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22De+Giorgio+F%22">De Giorgio F</searchLink>; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez+J%22">Gonzalez J</searchLink>; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Josep Carreras Leukemia Research Institute (IJC), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Iglesias+A%22">Iglesias A</searchLink>; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Josep Carreras Leukemia Research Institute (IJC), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Berenguer-Balaguer+C%22">Berenguer-Balaguer C</searchLink>; Department of Medicine and Life Sciences, Endocrine Regulatory Genomics, Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Schilling+M%22">Schilling M</searchLink>; Gene Regulation of Cell Identity Lab, Neurosciences Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Plass+M%22">Plass M</searchLink>; Gene Regulation of Cell Identity Lab, Neurosciences Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Spain.; Physiological Sciences Department, Faculty of Medicine and Health Sciences, University of Barcelona, L'Hospitalet del Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Pasquali+L%22">Pasquali L</searchLink>; Department of Medicine and Life Sciences, Endocrine Regulatory Genomics, Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Català+A%22">Català A</searchLink>; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain.; Instituto de Salud Carlos III, Biomedical Network Research Centre on Rare Diseases, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Molina+O%22">Molina O</searchLink>; Department of Physiological Sciences, Genetics Section, School Of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain.; Josep Carreras Leukaemia Research Institute, School of Medicine, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wlodarski+MW%22">Wlodarski MW</searchLink>; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bigas+A%22">Bigas A</searchLink>; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Josep Carreras Leukemia Research Institute (IJC), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Giorgetti+A%22">Giorgetti A</searchLink>; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain. agiorgetti@idibell.cat.; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Barcelona University, Barcelona, Spain. agiorgetti@idibell.cat.; Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain. agiorgetti@idibell.cat.
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