CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness.
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| Title: | CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness. |
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| Authors: | Romero-Moya D; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Torralba-Sales E; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Calvo C; Department of Physiological Sciences, Genetics Section, School Of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain.; Josep Carreras Leukaemia Research Institute, School of Medicine, University of Barcelona, Barcelona, Spain., Marin-Bejar O; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.; Germans Trias i Pujol Health Science Research Institute (IGTP), Cancer Program, Badalona, Catalonia, Spain., Magallon-Mosella M; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Distefano M; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain., Pera J; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Castaño J; Hospital Sant Joan de Deu Advanced Therapies Platform, SJD Pediatric Cancer Center Barcelona (PCCB) building, Barcelona, Spain., De Giorgio F; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain., Gonzalez J; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Josep Carreras Leukemia Research Institute (IJC), Badalona, Spain., Iglesias A; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Josep Carreras Leukemia Research Institute (IJC), Badalona, Spain., Berenguer-Balaguer C; Department of Medicine and Life Sciences, Endocrine Regulatory Genomics, Universitat Pompeu Fabra (UPF), Barcelona, Spain., Schilling M; Gene Regulation of Cell Identity Lab, Neurosciences Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain., Plass M; Gene Regulation of Cell Identity Lab, Neurosciences Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Spain.; Physiological Sciences Department, Faculty of Medicine and Health Sciences, University of Barcelona, L'Hospitalet del Llobregat, Spain., Pasquali L; Department of Medicine and Life Sciences, Endocrine Regulatory Genomics, Universitat Pompeu Fabra (UPF), Barcelona, Spain., Català A; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain.; Instituto de Salud Carlos III, Biomedical Network Research Centre on Rare Diseases, Madrid, Spain., Molina O; Department of Physiological Sciences, Genetics Section, School Of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain.; Josep Carreras Leukaemia Research Institute, School of Medicine, University of Barcelona, Barcelona, Spain., Wlodarski MW; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Bigas A; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Josep Carreras Leukemia Research Institute (IJC), Badalona, Spain., Giorgetti A; Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain. agiorgetti@idibell.cat.; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Barcelona University, Barcelona, Spain. agiorgetti@idibell.cat.; Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain. agiorgetti@idibell.cat. |
| Source: | Leukemia [Leukemia] 2025 Dec; Vol. 39 (12), pp. 3015-3025. Date of Electronic Publication: 2025 Sep 15. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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