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Evaluating the diagnostic accuracy of WHO-recommended treatment decision algorithms for childhood tuberculosis using an individual person dataset: a study protocol.

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Title: Evaluating the diagnostic accuracy of WHO-recommended treatment decision algorithms for childhood tuberculosis using an individual person dataset: a study protocol.
Authors: Olbrich L; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munchen, Germany.; German Center for Infection Research Munich Site, Munchen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology, Infection and Pandemic Research, Munich, Germany., Larsson L; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munchen, Germany llarsson3@outlook.com., Dodd PJ; School of Health and Related Research, The University of Sheffield, Sheffield, UK., Palmer M; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Stellenbosch, South Africa., Nguyen MHTN; Bordeaux Population Health, University of Bordeaux, Talence, France., d'Elbée M; Bordeaux Population Health, University of Bordeaux, Talence, France., Hesseling AC; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Stellenbosch, South Africa., Heinrich N; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munchen, Germany.; German Center for Infection Research Munich Site, Munchen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology, Infection and Pandemic Research, Munich, Germany., Zar HJ; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.; Unit on Child and Adolescent Health, South African Medical Research Council, Cape Town, South Africa., Ntinginya NE; National Institute of Medical Research-Mbeya Medical Research Centre, Mbeya, United Republic of Tanzania., Khosa C; Instituto Nacional de Saude, Maputo, Mozambique., Nliwasa M; Helse Nord Tuberculosis Initiative, University of Malawi College of Medicine, Blantyre, Malawi., Verghese V; Department of Child Health, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India., Bonnet M; Institut de Recherche pour le Développement (IRD), Université de Montpellier, Montpellier, France., Wobudeya E; Mulago National Referral Hospital, Kampala, Uganda., Nduna B; Arthur Davidson Children's Hospital, Ndola, Zambia., Moh R; Programme PAC-CI, Abidjan, Lagunes, Côte d'Ivoire., Mwanga J; Epicentre Mbarara Research Centre, Mbarara, Uganda., Mustapha A; Ola During Children Hospital, Freetown, Sierra Leone., Breton G; Solthis, Paris, France., Taguebue JV; Chantal Biya International Reference Centre for HIV/AIDS Research on Prevention and Treatment, Yaounde, Cameroon., Borand L; Clinical Research Group, Epidemiology and Public Health Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia.; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD20600, USA., Marcy O; Bordeaux Population Health, University of Bordeaux, Talence, France., Chabala C; Department of Paediatrics, University of Zambia, Lusaka, Zambia.; Children's Hospital, University Teaching Hospital, Lusaka, Zambia., Seddon J; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Stellenbosch, South Africa.; Imperial College London, London, UK., van der Zalm MM; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Stellenbosch, South Africa.
Corporate Authors: Decide-TB Consortium, RaPaed-TB Consortium, TB-Speed Consortium, UMOYA Study Group
Source: BMJ open [BMJ Open] 2025 Sep 17; Vol. 15 (9), pp. e094954. Date of Electronic Publication: 2025 Sep 17.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Evaluating the diagnostic accuracy of WHO-recommended treatment decision algorithms for childhood tuberculosis using an individual person dataset: a study protocol.
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  Data: <searchLink fieldCode="AU" term="%22Olbrich+L%22">Olbrich L</searchLink>; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munchen, Germany.; German Center for Infection Research Munich Site, Munchen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology, Infection and Pandemic Research, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Larsson+L%22">Larsson L</searchLink>; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munchen, Germany llarsson3@outlook.com.<br /><searchLink fieldCode="AU" term="%22Dodd+PJ%22">Dodd PJ</searchLink>; School of Health and Related Research, The University of Sheffield, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Palmer+M%22">Palmer M</searchLink>; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Stellenbosch, South Africa.<br /><searchLink fieldCode="AU" term="%22Nguyen+MHTN%22">Nguyen MHTN</searchLink>; Bordeaux Population Health, University of Bordeaux, Talence, France.<br /><searchLink fieldCode="AU" term="%22d'Elbée+M%22">d'Elbée M</searchLink>; Bordeaux Population Health, University of Bordeaux, Talence, France.<br /><searchLink fieldCode="AU" term="%22Hesseling+AC%22">Hesseling AC</searchLink>; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Stellenbosch, South Africa.<br /><searchLink fieldCode="AU" term="%22Heinrich+N%22">Heinrich N</searchLink>; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munchen, Germany.; German Center for Infection Research Munich Site, Munchen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology, Infection and Pandemic Research, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zar+HJ%22">Zar HJ</searchLink>; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.; Unit on Child and Adolescent Health, South African Medical Research Council, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Ntinginya+NE%22">Ntinginya NE</searchLink>; National Institute of Medical Research-Mbeya Medical Research Centre, Mbeya, United Republic of Tanzania.<br /><searchLink fieldCode="AU" term="%22Khosa+C%22">Khosa C</searchLink>; Instituto Nacional de Saude, Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Nliwasa+M%22">Nliwasa M</searchLink>; Helse Nord Tuberculosis Initiative, University of Malawi College of Medicine, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Verghese+V%22">Verghese V</searchLink>; Department of Child Health, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.<br /><searchLink fieldCode="AU" term="%22Bonnet+M%22">Bonnet M</searchLink>; Institut de Recherche pour le Développement (IRD), Université de Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Wobudeya+E%22">Wobudeya E</searchLink>; 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Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD20600, USA.<br /><searchLink fieldCode="AU" term="%22Marcy+O%22">Marcy O</searchLink>; Bordeaux Population Health, University of Bordeaux, Talence, France.<br /><searchLink fieldCode="AU" term="%22Chabala+C%22">Chabala C</searchLink>; Department of Paediatrics, University of Zambia, Lusaka, Zambia.; Children's Hospital, University Teaching Hospital, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Seddon+J%22">Seddon J</searchLink>; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Stellenbosch, South Africa.; Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22van+der+Zalm+MM%22">van der Zalm MM</searchLink>; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Stellenbosch, South Africa.
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