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Single-cell RNA sequencing identifies CD8Teff cell activation as a predictive biomarker in triple-negative breast cancer immunotherapy.

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Title: Single-cell RNA sequencing identifies CD8Teff cell activation as a predictive biomarker in triple-negative breast cancer immunotherapy.
Authors: Mao L; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Zhang Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Chen Y; Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden., Peng Q; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Huang Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Ouyang W; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Zeng D; Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China., Ren W; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., He Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Li T; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Wang Z; Faculty of Innovation Engineering, Institute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao, China.; School of Computer and Information Engineering, Guangzhou Huali College, Guangzhou, China.; UMedEVO and UMedREVO Artificial Intelligence Technology (Guangzhou) Co., Ltd, Guangzhou, China., Lin R; Faculty of Innovation Engineering, Institute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao, China.; School of Computer and Information Engineering, Guangzhou Huali College, Guangzhou, China.; UMedEVO and UMedREVO Artificial Intelligence Technology (Guangzhou) Co., Ltd, Guangzhou, China., Zhao J; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. zhaojli5@mail.sysu.edu.cn., Wu J; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. king8702@163.com., Yao H; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. yaoherui@mail.sysu.edu.cn., Yu Y; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. yuyf9@mail.sysu.edu.cn.; Faculty of Innovation Engineering, Institute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao, China. yuyf9@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Cancer Pathogenesis and Precision Diagnosis and Treatment, AI Big Data Laboratory, Shenshan Medical Center, Memorial Hospital of Sun Yat-Sen University, Shanwei, China. yuyf9@mail.sysu.edu.cn.; Department of Breast Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China. yuyf9@mail.sysu.edu.cn.
Source: Molecular biomedicine [Mol Biomed] 2025 Sep 19; Vol. 6 (1), pp. 66. Date of Electronic Publication: 2025 Sep 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell RNA sequencing identifies CD8Teff cell activation as a predictive biomarker in triple-negative breast cancer immunotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Mao+L%22">Mao L</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Peng+Q%22">Peng Q</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+Z%22">Huang Z</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ouyang+W%22">Ouyang W</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zeng+D%22">Zeng D</searchLink>; Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ren+W%22">Ren W</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Faculty of Innovation Engineering, Institute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao, China.; School of Computer and Information Engineering, Guangzhou Huali College, Guangzhou, China.; UMedEVO and UMedREVO Artificial Intelligence Technology (Guangzhou) Co., Ltd, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+R%22">Lin R</searchLink>; Faculty of Innovation Engineering, Institute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao, China.; School of Computer and Information Engineering, Guangzhou Huali College, Guangzhou, China.; UMedEVO and UMedREVO Artificial Intelligence Technology (Guangzhou) Co., Ltd, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. zhaojli5@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. king8702@163.com.<br /><searchLink fieldCode="AU" term="%22Yao+H%22">Yao H</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. yaoherui@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. yuyf9@mail.sysu.edu.cn.; Faculty of Innovation Engineering, Institute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao, China. yuyf9@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Cancer Pathogenesis and Precision Diagnosis and Treatment, AI Big Data Laboratory, Shenshan Medical Center, Memorial Hospital of Sun Yat-Sen University, Shanwei, China. yuyf9@mail.sysu.edu.cn.; Department of Breast Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China. yuyf9@mail.sysu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229918283581406676%22">Molecular biomedicine</searchLink> [Mol Biomed] 2025 Sep 19; Vol. 6 (1), pp. 66. <i>Date of Electronic Publication: </i>2025 Sep 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918283581406676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8651 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628651%22">26628651 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biomed <i>Subsets: </i>MEDLINE
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