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Crosstalk via ICAM-1 enhances supportive phenotype of stellate cells and drives hepatocyte proliferation in iPSC-derived hepatic organoids.

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Title: Crosstalk via ICAM-1 enhances supportive phenotype of stellate cells and drives hepatocyte proliferation in iPSC-derived hepatic organoids.
Authors: Mochida T; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Miyoshi M; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Kakinuma S; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan; Department of Clinical and Diagnostic Laboratory Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan. Electronic address: skakinuma.gast@tmd.ac.jp., Shimizu T; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Tsuchiya J; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Watakabe K; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Inada K; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Kaneko S; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Kawai-Kitahata F; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Murakawa M; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Nitta S; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Nakagawa M; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan., Watanabe M; School of Medicine, Juntendo University, Tokyo, Japan., Asahina Y; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan; Division of Hepatic Medical Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan. Electronic address: asahina.gast@tmd.ac.jp., Okamoto R; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.
Source: Stem cell reports [Stem Cell Reports] 2025 Oct 14; Vol. 20 (10), pp. 102642. Date of Electronic Publication: 2025 Sep 18.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Crosstalk via ICAM-1 enhances supportive phenotype of stellate cells and drives hepatocyte proliferation in iPSC-derived hepatic organoids.
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  Data: <searchLink fieldCode="AU" term="%22Mochida+T%22">Mochida T</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Miyoshi+M%22">Miyoshi M</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kakinuma+S%22">Kakinuma S</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan; Department of Clinical and Diagnostic Laboratory Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan. Electronic address: skakinuma.gast@tmd.ac.jp.<br /><searchLink fieldCode="AU" term="%22Shimizu+T%22">Shimizu T</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuchiya+J%22">Tsuchiya J</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Watakabe+K%22">Watakabe K</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Inada+K%22">Inada K</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kaneko+S%22">Kaneko S</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kawai-Kitahata+F%22">Kawai-Kitahata F</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Murakawa+M%22">Murakawa M</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nitta+S%22">Nitta S</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagawa+M%22">Nakagawa M</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+M%22">Watanabe M</searchLink>; School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Asahina+Y%22">Asahina Y</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan; Division of Hepatic Medical Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan. Electronic address: asahina.gast@tmd.ac.jp.<br /><searchLink fieldCode="AU" term="%22Okamoto+R%22">Okamoto R</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101611300%22">Stem cell reports</searchLink> [Stem Cell Reports] 2025 Oct 14; Vol. 20 (10), pp. 102642. <i>Date of Electronic Publication: </i>2025 Sep 18.
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