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Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ9-tetrahydrocannabinol in older patients with poor appetite.

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Title: Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ9-tetrahydrocannabinol in older patients with poor appetite.
Authors: Storgaard IK; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Nielsen RL; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark., Houlind MB; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Bornæs O; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Christensen LWS; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Capital Region Pharmacy, Herlev, Denmark., Andersen AL; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark., Juul-Larsen HG; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark., Jørgensen LM; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Emergency Department, Copenhagen University Hospital, Amager and Hvidovre, Denmark., Breindahl T; Department of Clinical Biochemistry, North Denmark Regional Hospital, Hjørring, Denmark., Jawad BN; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Altintas I; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Emergency Department, Copenhagen University Hospital, Amager and Hvidovre, Denmark., Andersen O; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Emergency Department, Copenhagen University Hospital, Amager and Hvidovre, Denmark., Lund TM; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2026 Feb; Vol. 92 (2), pp. 504-514. Date of Electronic Publication: 2025 Sep 19.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
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  Data: Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ<superscript>9</superscript>-tetrahydrocannabinol in older patients with poor appetite.
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  Data: <searchLink fieldCode="AU" term="%22Storgaard+IK%22">Storgaard IK</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+RL%22">Nielsen RL</searchLink>; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Houlind+MB%22">Houlind MB</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bornæs+O%22">Bornæs O</searchLink>; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Christensen+LWS%22">Christensen LWS</searchLink>; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Capital Region Pharmacy, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+AL%22">Andersen AL</searchLink>; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Juul-Larsen+HG%22">Juul-Larsen HG</searchLink>; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Jørgensen+LM%22">Jørgensen LM</searchLink>; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Emergency Department, Copenhagen University Hospital, Amager and Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Breindahl+T%22">Breindahl T</searchLink>; Department of Clinical Biochemistry, North Denmark Regional Hospital, Hjørring, Denmark.<br /><searchLink fieldCode="AU" term="%22Jawad+BN%22">Jawad BN</searchLink>; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Altintas+I%22">Altintas I</searchLink>; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Emergency Department, Copenhagen University Hospital, Amager and Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+O%22">Andersen O</searchLink>; Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Emergency Department, Copenhagen University Hospital, Amager and Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Lund+TM%22">Lund TM</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
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  Data: <searchLink fieldCode="JN" term="%227503323%22">British journal of clinical pharmacology</searchLink> [Br J Clin Pharmacol] 2026 Feb; Vol. 92 (2), pp. 504-514. <i>Date of Electronic Publication: </i>2025 Sep 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7503323 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1365-2125 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203065251%22">03065251 </searchLink><i>NLM ISO Abbreviation: </i>Br J Clin Pharmacol <i>Subsets: </i>MEDLINE
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