Sustained efficacy of the RTS,S/AS01E malaria vaccine over 50 months of follow-up when used in full-dose or fractional-dose regimens in young children in Ghana and Kenya: final results from an open-label, phase 2b, randomised controlled trial.
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| Title: | Sustained efficacy of the RTS,S/AS01 |
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| Authors: | Osei-Tutu L; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Kariuki SK; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Lee CK; PATH's Center for Vaccine Innovation and Access, Washington, DC, USA., Fabre R; GSK, Wavre, Belgium., Bii DK; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Adjei S; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Oneko M; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Attobrah Sarfo MA; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Ockenhouse CF; PATH's Center for Vaccine Innovation and Access, Washington, DC, USA., Schuerman L; GSK, Wavre, Belgium., Buabeng PBY; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Bakari A; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Atieno C; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Kotoh-Mortty MF; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Otieno K; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Ntiamoah Y; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Sang T; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Bollaerts A; GSK, Wavre, Belgium., Westercamp N; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA., Ansong D; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Agbenyega T; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Samuels AM; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Kisumu, Kenya., Ofori-Anyinam O; GSK, Wavre, Belgium. Electronic address: opokua.ofori-anyinam@gsk.com. |
| Corporate Authors: | RTS,S study group |
| Source: | The Lancet. Global health [Lancet Glob Health] 2025 Oct; Vol. 13 (10), pp. e1723-e1736. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101613665 Publication Model: Print Cited Medium: Internet ISSN: 2214-109X (Electronic) Linking ISSN: 2214109X NLM ISO Abbreviation: Lancet Glob Health Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40975080 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sustained efficacy of the RTS,S/AS01<subscript>E</subscript> malaria vaccine over 50 months of follow-up when used in full-dose or fractional-dose regimens in young children in Ghana and Kenya: final results from an open-label, phase 2b, randomised controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Osei-Tutu+L%22">Osei-Tutu L</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Kariuki+SK%22">Kariuki SK</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Lee+CK%22">Lee CK</searchLink>; PATH's Center for Vaccine Innovation and Access, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Fabre+R%22">Fabre R</searchLink>; GSK, Wavre, Belgium.<br /><searchLink fieldCode="AU" term="%22Bii+DK%22">Bii DK</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Adjei+S%22">Adjei S</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Oneko+M%22">Oneko M</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Attobrah+Sarfo+MA%22">Attobrah Sarfo MA</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Ockenhouse+CF%22">Ockenhouse CF</searchLink>; PATH's Center for Vaccine Innovation and Access, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Schuerman+L%22">Schuerman L</searchLink>; GSK, Wavre, Belgium.<br /><searchLink fieldCode="AU" term="%22Buabeng+PBY%22">Buabeng PBY</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Bakari+A%22">Bakari A</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Atieno+C%22">Atieno C</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Kotoh-Mortty+MF%22">Kotoh-Mortty MF</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Otieno+K%22">Otieno K</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Ntiamoah+Y%22">Ntiamoah Y</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Sang+T%22">Sang T</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Bollaerts+A%22">Bollaerts A</searchLink>; GSK, Wavre, Belgium.<br /><searchLink fieldCode="AU" term="%22Westercamp+N%22">Westercamp N</searchLink>; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ansong+D%22">Ansong D</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Agbenyega+T%22">Agbenyega T</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Samuels+AM%22">Samuels AM</searchLink>; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Ofori-Anyinam+O%22">Ofori-Anyinam O</searchLink>; GSK, Wavre, Belgium. Electronic address: opokua.ofori-anyinam@gsk.com. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22RTS%2CS+study+group%22">RTS,S study group</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101613665%22">The Lancet. Global health</searchLink> [Lancet Glob Health] 2025 Oct; Vol. 13 (10), pp. e1723-e1736. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101613665 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2214-109X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222214109X%22">2214109X </searchLink><i>NLM ISO Abbreviation: </i>Lancet Glob Health <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40975080 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S2214-109X(25)00272-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e1723 Titles: – TitleFull: Sustained efficacy of the RTS,S/AS01E malaria vaccine over 50 months of follow-up when used in full-dose or fractional-dose regimens in young children in Ghana and Kenya: final results from an open-label, phase 2b, randomised controlled trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Osei-Tutu L – PersonEntity: Name: NameFull: Kariuki SK – PersonEntity: Name: NameFull: Lee CK – PersonEntity: Name: NameFull: Fabre R – PersonEntity: Name: NameFull: Bii DK – PersonEntity: Name: NameFull: Adjei S – PersonEntity: Name: NameFull: Oneko M – PersonEntity: Name: NameFull: Attobrah Sarfo MA – PersonEntity: Name: NameFull: Ockenhouse CF – PersonEntity: Name: NameFull: Schuerman L – PersonEntity: Name: NameFull: Buabeng PBY – PersonEntity: Name: NameFull: Bakari A – PersonEntity: Name: NameFull: Atieno C – PersonEntity: Name: NameFull: Kotoh-Mortty MF – PersonEntity: Name: NameFull: Otieno K – PersonEntity: Name: NameFull: Ntiamoah Y – PersonEntity: Name: NameFull: Sang T – PersonEntity: Name: NameFull: Bollaerts A – PersonEntity: Name: NameFull: Westercamp N – PersonEntity: Name: NameFull: Ansong D – PersonEntity: Name: NameFull: Agbenyega T – PersonEntity: Name: NameFull: Samuels AM – PersonEntity: Name: NameFull: Ofori-Anyinam O IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: 2025 Oct Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2214-109X Numbering: – Type: volume Value: 13 – Type: issue Value: 10 Titles: – TitleFull: The Lancet. Global health Type: main |
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