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Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression.

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Title: Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression.
Authors: Shimizu T; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Ohkuma R; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Homma M; Department of Pathology, Showa Medical University School of Medicine, Tokyo, Japan., Nakayama S; Department of Pathology, Showa Medical University School of Medicine, Tokyo, Japan., Sasaki Y; Department of Pathology, Showa Medical University School of Medicine, Tokyo, Japan., Muto S; Department of Chest Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan., Ieguchi K; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Watanabe M; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, School of Medicine, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan., Taguchi A; Isotope Science Center, The University of Tokyo, Tokyo, Japan., Takayanagi D; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Wada Y; Isotope Science Center, The University of Tokyo, Tokyo, Japan., Horiike A; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Kubota Y; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Ariizumi H; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Shimokawa M; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Hirasawa Y; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Ishiguro T; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Suzuki R; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Iriguchi N; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Mura E; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Yoshimura K; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Chest Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan., Tsuji M; Department of Pharmacology, School of Medicine, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan., Kiuchi Y; Department of Pharmacology, School of Medicine, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Showa Medical University College of Nursing, Tokyo, Japan., Suzuki H; Department of Chest Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan., Yamochi T; Department of Pathology, Showa Medical University School of Medicine, Tokyo, Japan.
Source: Frontiers in immunology [Front Immunol] 2025 Sep 08; Vol. 16, pp. 1528594. Date of Electronic Publication: 2025 Sep 08 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression.
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  Data: <searchLink fieldCode="AU" term="%22Shimizu+T%22">Shimizu T</searchLink>; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ohkuma+R%22">Ohkuma R</searchLink>; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Homma+M%22">Homma M</searchLink>; Department of Pathology, Showa Medical University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakayama+S%22">Nakayama S</searchLink>; Department of Pathology, Showa Medical University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sasaki+Y%22">Sasaki Y</searchLink>; Department of Pathology, Showa Medical University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Muto+S%22">Muto S</searchLink>; Department of Chest Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.<br /><searchLink fieldCode="AU" term="%22Ieguchi+K%22">Ieguchi K</searchLink>; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+M%22">Watanabe M</searchLink>; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, School of Medicine, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Taguchi+A%22">Taguchi A</searchLink>; Isotope Science Center, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takayanagi+D%22">Takayanagi D</searchLink>; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Wada+Y%22">Wada Y</searchLink>; Isotope Science Center, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Horiike+A%22">Horiike A</searchLink>; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kubota+Y%22">Kubota Y</searchLink>; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ariizumi+H%22">Ariizumi H</searchLink>; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shimokawa+M%22">Shimokawa M</searchLink>; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hirasawa+Y%22">Hirasawa Y</searchLink>; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ishiguro+T%22">Ishiguro T</searchLink>; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+R%22">Suzuki R</searchLink>; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Iriguchi+N%22">Iriguchi N</searchLink>; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Mura+E%22">Mura E</searchLink>; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshimura+K%22">Yoshimura K</searchLink>; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Chest Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuji+M%22">Tsuji M</searchLink>; Department of Pharmacology, School of Medicine, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kiuchi+Y%22">Kiuchi Y</searchLink>; Department of Pharmacology, School of Medicine, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Showa Medical University College of Nursing, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+H%22">Suzuki H</searchLink>; Department of Chest Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.<br /><searchLink fieldCode="AU" term="%22Yamochi+T%22">Yamochi T</searchLink>; Department of Pathology, Showa Medical University School of Medicine, Tokyo, Japan.
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