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Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α.

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Title: Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α.
Authors: Khetarpal SA; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.; Robert M. Berne Cardiovascular Research Center and Division of Cardiology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA., Li H; Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Massachusetts General Hospital, and the Massachusetts General Research Institute, Boston, MA, USA., Vitale T; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Rhee J; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Massachusetts General Hospital, and the Massachusetts General Research Institute, Boston, MA, USA., Challa S; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Castro C; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Pabel S; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sun Y; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Liu J; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA., Bogoslavski D; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Vargas-Castillo A; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Smythers AL; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Blackmore KA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Grauvogel L; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Mittenbühler MJ; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Khandekar MJ; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Curtin C; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA., Narvaez-Paliza JM; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA., Wang C; Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Massachusetts General Hospital, and the Massachusetts General Research Institute, Boston, MA, USA., Houstis NE; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Sprenger HG; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Jurgens SJ; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Experimental Cardiology and Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Biddinger KJ; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kuznetsov A; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Freeman R; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Ellinor PT; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Disease Initiative, the Broad Institute of Harvard and MIT, Cambridge, MA, USA., Nahrendorf M; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Dumesic PA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Asnani A; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA., Aragam KG; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Puigserver P; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Roh JD; Corrigan Minehan Heart Center and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Spiegelman BM; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA. bruce_spiegelman@dfci.harvard.edu.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. bruce_spiegelman@dfci.harvard.edu., Rosenzweig A; Stanley and Judith Frankel Institute for Heart and Brain Health, University of Michigan, Ann Arbor, MI, USA. anthros@med.umich.edu.
Source: Nature cardiovascular research [Nat Cardiovasc Res] 2025 Oct; Vol. 4 (10), pp. 1277-1294. Date of Electronic Publication: 2025 Sep 24.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE
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