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Metal-polyphenol network-engineered mesenchymal stem cell-derived exosome mimetics mediate inflammatory/immune regulation for enhanced periodontal tissue regeneration.

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Title: Metal-polyphenol network-engineered mesenchymal stem cell-derived exosome mimetics mediate inflammatory/immune regulation for enhanced periodontal tissue regeneration.
Authors: Zhou ZY; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China., Li ZB; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China., Shi NS; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China., Feng SS; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China., Han YR; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China., Liu MT; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China., Chen H; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China., Li JH; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China. Electronic address: jianhua.li@sdu.edu.cn., Ge SH; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China. Electronic address: shaohuage@sdu.edu.cn., Yu Y; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China. Electronic address: yuyang_dentist@sdu.edu.cn.
Source: Biomaterials [Biomaterials] 2026 Apr; Vol. 327, pp. 123696. Date of Electronic Publication: 2025 Sep 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
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  Data: Metal-polyphenol network-engineered mesenchymal stem cell-derived exosome mimetics mediate inflammatory/immune regulation for enhanced periodontal tissue regeneration.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+ZY%22">Zhou ZY</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Li+ZB%22">Li ZB</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Shi+NS%22">Shi NS</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Feng+SS%22">Feng SS</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Han+YR%22">Han YR</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Liu+MT%22">Liu MT</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Li+JH%22">Li JH</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China. Electronic address: jianhua.li@sdu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ge+SH%22">Ge SH</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China. Electronic address: shaohuage@sdu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Department of Endodontics & Periodontology & Biomaterial, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China. Electronic address: yuyang_dentist@sdu.edu.cn.
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              Text: 2026 Apr
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