Assessing the Impact of SARS-CoV-2 Spike Mutations on Antibody Binding: A Comparative Assessment of the Wuhan and JN.1 Variants' Full-Length Spikes in a Multiplex Luminex Assay.

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Title: Assessing the Impact of SARS-CoV-2 Spike Mutations on Antibody Binding: A Comparative Assessment of the Wuhan and JN.1 Variants' Full-Length Spikes in a Multiplex Luminex Assay.
Authors: Waweru G; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; School of Pure and Applied Sciences, Department of Biological Sciences, Pwani University, Kilifi P.O. Box 195-80108, Kenya., Nyakundi R; Kenya Institute of Primate Research, Nairobi P.O. Box 24481 00502, Kenya., Kutima B; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Owuor S; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Konyino G; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Gitonga J; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Lugano D; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Maina A; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Musyoki J; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Ochola L; Kenya Institute of Primate Research, Nairobi P.O. Box 24481 00502, Kenya., Omondi M; Kenya Institute of Primate Research, Nairobi P.O. Box 24481 00502, Kenya., Kariuki CK; Kenya Institute of Primate Research, Nairobi P.O. Box 24481 00502, Kenya., Ogongo P; Kenya Institute of Primate Research, Nairobi P.O. Box 24481 00502, Kenya., Mwachari C; Kenya Medical Research Institute, Nairobi P.O. Box 54840 00200, Kenya., Shee F; School of Pure and Applied Sciences, Department of Biological Sciences, Pwani University, Kilifi P.O. Box 195-80108, Kenya., Agoti C; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Sande C; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Uyoga S; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Kagucia E; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Agweyu A; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Bejon P; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; Nuffield Department of Medicine, Oxford University, Oxford OX3 7BN, UK., Scott JAG; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Warimwe GM; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; Nuffield Department of Medicine, Oxford University, Oxford OX3 7BN, UK., Ochola-Oyier LI; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya., Nyagwange J; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.
Source: Viruses [Viruses] 2025 Sep 16; Vol. 17 (9). Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Assessing the Impact of SARS-CoV-2 Spike Mutations on Antibody Binding: A Comparative Assessment of the Wuhan and JN.1 Variants' Full-Length Spikes in a Multiplex Luminex Assay.
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  Data: <searchLink fieldCode="AU" term="%22Waweru+G%22">Waweru G</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; School of Pure and Applied Sciences, Department of Biological Sciences, Pwani University, Kilifi P.O. Box 195-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Nyakundi+R%22">Nyakundi R</searchLink>; Kenya Institute of Primate Research, Nairobi P.O. Box 24481 00502, Kenya.<br /><searchLink fieldCode="AU" term="%22Kutima+B%22">Kutima B</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Owuor+S%22">Owuor S</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Konyino+G%22">Konyino G</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Gitonga+J%22">Gitonga J</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Lugano+D%22">Lugano D</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Maina+A%22">Maina A</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. 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Box 54840 00200, Kenya.<br /><searchLink fieldCode="AU" term="%22Shee+F%22">Shee F</searchLink>; School of Pure and Applied Sciences, Department of Biological Sciences, Pwani University, Kilifi P.O. Box 195-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Agoti+C%22">Agoti C</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Sande+C%22">Sande C</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Uyoga+S%22">Uyoga S</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Kagucia+E%22">Kagucia E</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Agweyu+A%22">Agweyu A</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.<br /><searchLink fieldCode="AU" term="%22Bejon+P%22">Bejon P</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; Nuffield Department of Medicine, Oxford University, Oxford OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Scott+JAG%22">Scott JAG</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.<br /><searchLink fieldCode="AU" term="%22Warimwe+GM%22">Warimwe GM</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.; Nuffield Department of Medicine, Oxford University, Oxford OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Ochola-Oyier+LI%22">Ochola-Oyier LI</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.<br /><searchLink fieldCode="AU" term="%22Nyagwange+J%22">Nyagwange J</searchLink>; KEMRI-Wellcome Trust Research Programme, Center for Geographic Medicine Research, Coast, Kilifi P.O. Box 230-80108, Kenya.
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