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Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures.

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Title: Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures.
Authors: Hsu HE; Institute of Chemistry, Academia Sinica, Taipei, Taiwan., Martin MJ; Oncology Targeted Discovery, Oncology R&D, AstraZeneca, Cambridge, UK., Weng SH; Institute of Chemistry, Academia Sinica, Taipei, Taiwan., Kitata RB; Institute of Chemistry, Academia Sinica, Taipei, Taiwan., Nagelli S; Oncology Targeted Discovery, Oncology R&D, AstraZeneca, Cambridge, UK., Chang CY; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Hess S; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA. Sonja.Hess@astrazeneca.com., Chen YJ; Institute of Chemistry, Academia Sinica, Taipei, Taiwan. yujuchen@as.edu.tw.; Department of Chemistry, National Taiwan University, Taipei, Taiwan. yujuchen@as.edu.tw.
Source: Molecular systems biology [Mol Syst Biol] 2025 Nov; Vol. 21 (11), pp. 1547-1562. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures.
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  Data: <searchLink fieldCode="AU" term="%22Hsu+HE%22">Hsu HE</searchLink>; Institute of Chemistry, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Martin+MJ%22">Martin MJ</searchLink>; Oncology Targeted Discovery, Oncology R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Weng+SH%22">Weng SH</searchLink>; Institute of Chemistry, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kitata+RB%22">Kitata RB</searchLink>; Institute of Chemistry, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Nagelli+S%22">Nagelli S</searchLink>; Oncology Targeted Discovery, Oncology R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Chang+CY%22">Chang CY</searchLink>; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hess+S%22">Hess S</searchLink>; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA. Sonja.Hess@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; Institute of Chemistry, Academia Sinica, Taipei, Taiwan. yujuchen@as.edu.tw.; Department of Chemistry, National Taiwan University, Taipei, Taiwan. yujuchen@as.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101235389%22">Molecular systems biology</searchLink> [Mol Syst Biol] 2025 Nov; Vol. 21 (11), pp. 1547-1562. <i>Date of Electronic Publication: </i>2025 Sep 29.
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        Value: 10.1038/s44320-025-00141-1
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              Text: 2025 Nov
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