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A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites.

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Title: A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites.
Authors: Maher SP; Center for Tropical and Emerging Global Disease, University of Georgia, Athens, United States., Bakowski MA; Calibr, a division of The Scripps Research Institute, La Jolla, United States., Vantaux A; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia., Flannery EL; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States., Andolina C; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mae Sot, Thailand., Gupta M; Department of Molecular, Cell, and Systems Biology, University of California, Riverside, Riverside, United States., Antonova-Koch Y; Calibr, a division of The Scripps Research Institute, La Jolla, United States., Argomaniz M; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States., Cabrera-Mora M; International Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, United States., Campo B; Medicines for Malaria Venture (MMV), Geneva, Switzerland., Chao AT; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States., Chatterjee AK; Calibr, a division of The Scripps Research Institute, La Jolla, United States., Cheng WT; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States., Chuenchob V; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States., Cooper CA; Center for Tropical and Emerging Global Disease, University of Georgia, Athens, United States., Cottier K; BioIVT Inc, New York, United States., Galinski MR; International Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, United States.; Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, United States., Harupa-Chung A; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States., Ji H; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States., Joseph SB; Calibr, a division of The Scripps Research Institute, La Jolla, United States., Lenz T; Department of Molecular, Cell, and Systems Biology, University of California, Riverside, Riverside, United States., Lonardi S; Department of Computer Science and Engineering, University of California, Riverside, Riverside, United States., Matheson J; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand., Mikolajczak SA; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States., Moeller T; BioIVT Inc, New York, United States., Orban A; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia., Padín-Irizarry V; Center for Tropical and Emerging Global Disease, University of Georgia, Athens, United States.; School of Sciences, Clayton State University, Morrow, United States., Pan K; Calibr, a division of The Scripps Research Institute, La Jolla, United States., Péneau J; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia., Prudhomme J; Department of Molecular, Cell, and Systems Biology, University of California, Riverside, Riverside, United States., Roesch C; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia., Ruberto A; Center for Tropical and Emerging Global Disease, University of Georgia, Athens, United States., Sabnis SS; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States., Saney CL; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States., Sattabongkot J; Mahidol Vivax Research Unit, Mahidol University, Bangkok, Thailand., Sereshki S; Department of Computer Science and Engineering, University of California, Riverside, Riverside, United States., Suriyakan S; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mae Sot, Thailand., Ubalee R; Department of Entomology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand., Wang Y; Department of Chemistry, University of California, Riverside, Riverside, United States.; Environmental Toxicology Graduate Program, University of California, Riverside, Riverside, United States., Wasisakun P; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mae Sot, Thailand., Yin J; Environmental Toxicology Graduate Program, University of California, Riverside, Riverside, United States., Popovici J; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia., McNamara CW; Calibr, a division of The Scripps Research Institute, La Jolla, United States., Joyner C; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States.; International Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, United States., Nosten FH; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mae Sot, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Witkowski B; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia., Le Roch KG; Department of Molecular, Cell, and Systems Biology, University of California, Riverside, Riverside, United States., Kyle DE; Center for Tropical and Emerging Global Disease, University of Georgia, Athens, United States.
Source: ELife [Elife] 2025 Sep 30; Vol. 13. Date of Electronic Publication: 2025 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites.
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Department of Molecular, Cell, and Systems Biology, University of California, Riverside, Riverside, United States.<br /><searchLink fieldCode="AU" term="%22Roesch+C%22">Roesch C</searchLink>; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia.<br /><searchLink fieldCode="AU" term="%22Ruberto+A%22">Ruberto A</searchLink>; Center for Tropical and Emerging Global Disease, University of Georgia, Athens, United States.<br /><searchLink fieldCode="AU" term="%22Sabnis+SS%22">Sabnis SS</searchLink>; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States.<br /><searchLink fieldCode="AU" term="%22Saney+CL%22">Saney CL</searchLink>; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States.<br /><searchLink fieldCode="AU" term="%22Sattabongkot+J%22">Sattabongkot J</searchLink>; Mahidol Vivax Research Unit, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Sereshki+S%22">Sereshki S</searchLink>; 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