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Phase-separated NDF-FACT condensates facilitate transcription elongation on chromatin.

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Title: Phase-separated NDF-FACT condensates facilitate transcription elongation on chromatin.
Authors: Li Z; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA., Burgos-Bravo F; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA.; Jason Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, CA, USA., Xu K; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA., Li C; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA.; Jason Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, CA, USA., Kwan KY; Department of Cell Biology and Neurosciences, Rutgers University, Piscataway, NJ, USA., Tong AB; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA.; Jason Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, CA, USA., Shan Z; The Salk Institute for Biological Studies, La Jolla, CA, USA., Wang H; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA., Takaku M; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA., Li J; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA., Shi Z; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA.; Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA., Lyumkis D; The Salk Institute for Biological Studies, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.; Graduate School of Biological Sciences, Section of Molecular Biology, University of California San Diego, La Jolla, CA, USA., Bustamante C; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Jason Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Biophysics Graduate Group, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Department of Chemistry, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Kavli Energy Nanoscience Institute, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Department of Physics, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Molecular Biophysics and Integrative Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. carlosb@berkeley.edu., Fei J; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA. jia.fei@rutgers.edu.; Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA. jia.fei@rutgers.edu.
Source: Nature cell biology [Nat Cell Biol] 2025 Nov; Vol. 27 (11), pp. 1938-1951. Date of Electronic Publication: 2025 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
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  Data: Phase-separated NDF-FACT condensates facilitate transcription elongation on chromatin.
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  Data: <searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Burgos-Bravo+F%22">Burgos-Bravo F</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA.; Jason Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA.; Jason Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kwan+KY%22">Kwan KY</searchLink>; Department of Cell Biology and Neurosciences, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Tong+AB%22">Tong AB</searchLink>; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA.; Jason Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shan+Z%22">Shan Z</searchLink>; The Salk Institute for Biological Studies, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Takaku+M%22">Takaku M</searchLink>; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA.; Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Lyumkis+D%22">Lyumkis D</searchLink>; The Salk Institute for Biological Studies, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.; Graduate School of Biological Sciences, Section of Molecular Biology, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bustamante+C%22">Bustamante C</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Jason Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Biophysics Graduate Group, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Department of Chemistry, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Kavli Energy Nanoscience Institute, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Department of Physics, University of California, Berkeley, CA, USA. carlosb@berkeley.edu.; Molecular Biophysics and Integrative Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. carlosb@berkeley.edu.<br /><searchLink fieldCode="AU" term="%22Fei+J%22">Fei J</searchLink>; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA. jia.fei@rutgers.edu.; Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA. jia.fei@rutgers.edu.
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