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SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis.

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Title: SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis.
Authors: Ullrich Gavilanes EM; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany., Bartos LM; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Gernert JA; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany., Carral CA; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany., Ruiz Navarro D; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany., Havla J; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany., Gerdes LA; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.; Munich Cluster of Systems Neurology (SyNergy), 81377 Munich, Germany., Gnörich JS; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Kunze LH; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Dorneich JS; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Pakula V; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Tagnin L; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Zimmermann H; Institute of Neuroradiology, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Seelos K; Institute of Neuroradiology, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Franzmeier N; Munich Cluster of Systems Neurology (SyNergy), 81377 Munich, Germany.; Institute for Stroke and Dementia Research, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Department of Psychiatry and Neurochemistry, University of Gothenburg, Sahlgrenska Academy, Institute of Neuroscience and Physiology, 43133 Mölndal and 41345 Gothenburg, Sweden., Frontzkowski L; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Institute for Stroke and Dementia Research, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Pedrosa de Barros N; Icometrix, 3012 Leuven, Belgium., Ribbens A; Icometrix, 3012 Leuven, Belgium., Zwergal RM; Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Zwergal A; Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; German Center for Vertigo and Balance Disorders (DSGZ), LMU University Hospital, LMU Munich, 81377 Munich, Germany., Vollmar C; Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Remi J; Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Picon C; Division of Clinical Pathology, Geneva University Hospital, 1205 Geneva, Switzerland.; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland., Reynolds R; Department of Brain Sciences, UK Multiple Sclerosis Society Tissue Bank, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, W12 0NN London, UK., Merkler D; Division of Clinical Pathology, Geneva University Hospital, 1205 Geneva, Switzerland.; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland., Wattjes MP; Department of Neuroradiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 12203 Berlin, Germany., Kümpfel T; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany., Brendel M; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), 81377 Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Kerschensteiner M; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.; Munich Cluster of Systems Neurology (SyNergy), 81377 Munich, Germany.
Source: Science translational medicine [Sci Transl Med] 2025 Oct; Vol. 17 (818), pp. eadt5585. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Ullrich+Gavilanes+EM%22">Ullrich Gavilanes EM</searchLink>; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Bartos+LM%22">Bartos LM</searchLink>; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gernert+JA%22">Gernert JA</searchLink>; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Carral+CA%22">Carral CA</searchLink>; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; 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Department of Brain Sciences, UK Multiple Sclerosis Society Tissue Bank, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, W12 0NN London, UK.<br /><searchLink fieldCode="AU" term="%22Merkler+D%22">Merkler D</searchLink>; Division of Clinical Pathology, Geneva University Hospital, 1205 Geneva, Switzerland.; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wattjes+MP%22">Wattjes MP</searchLink>; Department of Neuroradiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 12203 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kümpfel+T%22">Kümpfel T</searchLink>; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Brendel+M%22">Brendel M</searchLink>; 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