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Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis.

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Title: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis.
Authors: Michaelis T; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA., Lindestam Arlehamn CS; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Center for Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark., Johansson E; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden., Frazier A; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA., Williams GP; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA., Berry JD; Sean M. Healey and AMG Center for ALS, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Cudkowicz M; Sean M. Healey and AMG Center for ALS, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Goyal NA; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Fournier C; Department of Neurology, Emory University, Atlanta, GA, USA., Snyder A; Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kwan JY; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Crook J; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Phillips EJ; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.; Vanderbilt University School of Medicine, Nashville, TN, USA., Mallal SA; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.; Vanderbilt University School of Medicine, Nashville, TN, USA., Ravits J; Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA., Marder KS; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Sidney J; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA., Sulzer D; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA. ds43@cumc.columbia.edu.; Departments of Psychiatry, Neurology and Pharmacology, Columbia University, New York, NY, USA. ds43@cumc.columbia.edu., Sette A; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA. alex@lji.org.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, USA. alex@lji.org.
Source: Nature [Nature] 2025 Nov; Vol. 647 (8091), pp. 970-978. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Michaelis+T%22">Michaelis T</searchLink>; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lindestam+Arlehamn+CS%22">Lindestam Arlehamn CS</searchLink>; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Center for Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Johansson+E%22">Johansson E</searchLink>; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Frazier+A%22">Frazier A</searchLink>; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Williams+GP%22">Williams GP</searchLink>; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Berry+JD%22">Berry JD</searchLink>; Sean M. Healey and AMG Center for ALS, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cudkowicz+M%22">Cudkowicz M</searchLink>; Sean M. Healey and AMG Center for ALS, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goyal+NA%22">Goyal NA</searchLink>; Department of Neurology, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fournier+C%22">Fournier C</searchLink>; Department of Neurology, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Snyder+A%22">Snyder A</searchLink>; Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kwan+JY%22">Kwan JY</searchLink>; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Crook+J%22">Crook J</searchLink>; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Phillips+EJ%22">Phillips EJ</searchLink>; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.; Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Mallal+SA%22">Mallal SA</searchLink>; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.; Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ravits+J%22">Ravits J</searchLink>; Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Marder+KS%22">Marder KS</searchLink>; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sidney+J%22">Sidney J</searchLink>; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sulzer+D%22">Sulzer D</searchLink>; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA. ds43@cumc.columbia.edu.; Departments of Psychiatry, Neurology and Pharmacology, Columbia University, New York, NY, USA. ds43@cumc.columbia.edu.<br /><searchLink fieldCode="AU" term="%22Sette+A%22">Sette A</searchLink>; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA. alex@lji.org.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, USA. alex@lji.org.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2025 Nov; Vol. 647 (8091), pp. 970-978. <i>Date of Electronic Publication: </i>2025 Oct 01.
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