Decoding adipose-brain crosstalk: Distinct lipid cargo in human adipose-derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease.

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Title: Decoding adipose-brain crosstalk: Distinct lipid cargo in human adipose-derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease.
Authors: Yang L; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA., Chan M; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA., Sheng J; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA., Qi S; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA., Chan B; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA., Shantaram D; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Rima XY; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Reategui E; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Han X; Barshop Institute for Longevity and Aging Studies, and Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Hsueh WA; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Wong STC; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA.; Departments of Medicine, Radiology, Neurology, Pathology and Laboratory Medicine, Houston Methodist Hospital and Weill Cornell Medicine, Houston, Texas, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70603.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
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  Data: Decoding adipose-brain crosstalk: Distinct lipid cargo in human adipose-derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Chan+M%22">Chan M</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Sheng+J%22">Sheng J</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Qi+S%22">Qi S</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Chan+B%22">Chan B</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Shantaram+D%22">Shantaram D</searchLink>; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Rima+XY%22">Rima XY</searchLink>; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Reategui+E%22">Reategui E</searchLink>; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Han+X%22">Han X</searchLink>; Barshop Institute for Longevity and Aging Studies, and Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Hsueh+WA%22">Hsueh WA</searchLink>; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Wong+STC%22">Wong STC</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, Texas, USA.; Departments of Medicine, Radiology, Neurology, Pathology and Laboratory Medicine, Houston Methodist Hospital and Weill Cornell Medicine, Houston, Texas, USA.
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              Text: 2025 Oct
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