Risk factor identification for delayed excretion in pediatric high-dose methotrexate therapy: a machine learning analysis of real-world data.

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Title: Risk factor identification for delayed excretion in pediatric high-dose methotrexate therapy: a machine learning analysis of real-world data.
Authors: Zhou C; Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China.; Department of Pediatrics, The Second People's Hospital of Changzhou Affiliated to Nanjing Medical University, Nanjing, China., Qian Y; Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China., Xue Y; Department of Hematology, Children's Hospital of Nanjing Medical University, Nanjing, China., Rong L; Department of Hematology, Children's Hospital of Nanjing Medical University, Nanjing, China., Wan Y; Department of Pediatrics, The Second People's Hospital of Changzhou Affiliated to Nanjing Medical University, Nanjing, China., Leng K; Department of Pediatrics, The Second People's Hospital of Changzhou Affiliated to Nanjing Medical University, Nanjing, China., Miao H; Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China., Chen F; Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China., Fang Y; Department of Hematology, Children's Hospital of Nanjing Medical University, Nanjing, China., Ge X; Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China.; Jiangsu Key Laboratory of Children's Major Disease Research, Children's Hospital of Nanjing Medical University, Nanjing, China.
Source: Frontiers in pharmacology [Front Pharmacol] 2025 Sep 17; Vol. 16, pp. 1662718. Date of Electronic Publication: 2025 Sep 17 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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  Data: Risk factor identification for delayed excretion in pediatric high-dose methotrexate therapy: a machine learning analysis of real-world data.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China.; Department of Pediatrics, The Second People's Hospital of Changzhou Affiliated to Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Qian+Y%22">Qian Y</searchLink>; Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Xue+Y%22">Xue Y</searchLink>; Department of Hematology, Children's Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Rong+L%22">Rong L</searchLink>; Department of Hematology, Children's Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wan+Y%22">Wan Y</searchLink>; Department of Pediatrics, The Second People's Hospital of Changzhou Affiliated to Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Leng+K%22">Leng K</searchLink>; Department of Pediatrics, The Second People's Hospital of Changzhou Affiliated to Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Miao+H%22">Miao H</searchLink>; Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Fang+Y%22">Fang Y</searchLink>; Department of Hematology, Children's Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ge+X%22">Ge X</searchLink>; Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China.; Jiangsu Key Laboratory of Children's Major Disease Research, Children's Hospital of Nanjing Medical University, Nanjing, China.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2025 Sep 17; Vol. 16, pp. 1662718. <i>Date of Electronic Publication: </i>2025 Sep 17 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 Sep 17
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