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Tetrahydrocurcumin Protects Microglial Cells Against Pseudomonas aeruginosa Lipopolysaccharide-Induced Reactive Oxygen Species Production and Cathepsin B to Activate NLRP3 Inflammasome-Mediated Pyroptosis Via the HO-1 and p38/JNK Pathway.

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Title: Tetrahydrocurcumin Protects Microglial Cells Against Pseudomonas aeruginosa Lipopolysaccharide-Induced Reactive Oxygen Species Production and Cathepsin B to Activate NLRP3 Inflammasome-Mediated Pyroptosis Via the HO-1 and p38/JNK Pathway.
Authors: Lin HW; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, 40201, Taichung, Taiwan., Chen TC; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan., Wang I; Rehabilitation Sciences & Technology, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA., Yeh JH; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan., Tsou SC; Department of Microbiology and Immunology, School of Medicine, Chung-Shan Medical University, and Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan., Sun L; Department of Optometry, Asia University, Taichung 413, Taiwan., Chung SC; Department of Nursing, Chung Shan Medical University, Taichung, 40201, Taiwan., Chuang CJ; Emergency department, St. Martin De Porres Hospital, Chiayi, 60069, Taiwan., Chang YY; Department of Microbiology and Immunology, School of Medicine, Chung-Shan Medical University, and Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Source: International journal of medical sciences [Int J Med Sci] 2025 Sep 21; Vol. 22 (15), pp. 4049-4062. Date of Electronic Publication: 2025 Sep 21 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: Tetrahydrocurcumin Protects Microglial Cells Against Pseudomonas aeruginosa Lipopolysaccharide-Induced Reactive Oxygen Species Production and Cathepsin B to Activate NLRP3 Inflammasome-Mediated Pyroptosis Via the HO-1 and p38/JNK Pathway.
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        Value: 10.7150/ijms.118252
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      – TitleFull: Tetrahydrocurcumin Protects Microglial Cells Against Pseudomonas aeruginosa Lipopolysaccharide-Induced Reactive Oxygen Species Production and Cathepsin B to Activate NLRP3 Inflammasome-Mediated Pyroptosis Via the HO-1 and p38/JNK Pathway.
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