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Novel anticancer effect of substituted imidazole derivatives against urothelial carcinoma: integrating In vitro screening and molecular docking for target kinases.

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Title: Novel anticancer effect of substituted imidazole derivatives against urothelial carcinoma: integrating In vitro screening and molecular docking for target kinases.
Authors: Aboulhoda BE; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, Egypt. basma.emad@kasralainy.edu.eg., Omar AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Elfarrash S; Department of Medical Physiology, Faculty of Medicine, Mansoura University, 35516, Mansoura, Egypt.; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., Alghamdi MA; Central Labs, King Khalid University, P.O. Box 960, AlQura'a, Abha, Saudi Arabia.; Department of Anatomy, College of Medicine, King Khalid University, Abha, 62529, Saudi Arabia.; Genomics and Personalized Medicine Unit, The Center for Medical and Health Research, King Khalid University, Abha, 62529, Saudi Arabia., Emam AA; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., El-Gamal R; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.; Department of Medical Biochemistry, Horus University- Egypt (HUE), Cairo, Egypt., Abo-Elhoda SE; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt., Zayed MF; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, 11884, Egypt.
Source: BMC cancer [BMC Cancer] 2025 Oct 06; Vol. 25 (1), pp. 1524. Date of Electronic Publication: 2025 Oct 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel anticancer effect of substituted imidazole derivatives against urothelial carcinoma: integrating In vitro screening and molecular docking for target kinases.
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  Data: <searchLink fieldCode="AU" term="%22Aboulhoda+BE%22">Aboulhoda BE</searchLink>; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, Egypt. basma.emad@kasralainy.edu.eg.<br /><searchLink fieldCode="AU" term="%22Omar+AM%22">Omar AM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elfarrash+S%22">Elfarrash S</searchLink>; Department of Medical Physiology, Faculty of Medicine, Mansoura University, 35516, Mansoura, Egypt.; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.<br /><searchLink fieldCode="AU" term="%22Alghamdi+MA%22">Alghamdi MA</searchLink>; Central Labs, King Khalid University, P.O. Box 960, AlQura'a, Abha, Saudi Arabia.; Department of Anatomy, College of Medicine, King Khalid University, Abha, 62529, Saudi Arabia.; Genomics and Personalized Medicine Unit, The Center for Medical and Health Research, King Khalid University, Abha, 62529, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Emam+AA%22">Emam AA</searchLink>; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Gamal+R%22">El-Gamal R</searchLink>; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.; Department of Medical Biochemistry, Horus University- Egypt (HUE), Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Abo-Elhoda+SE%22">Abo-Elhoda SE</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Zayed+MF%22">Zayed MF</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, 11884, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22100967800%22">BMC cancer</searchLink> [BMC Cancer] 2025 Oct 06; Vol. 25 (1), pp. 1524. <i>Date of Electronic Publication: </i>2025 Oct 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100967800 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1471-2407 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214712407%22">14712407 </searchLink><i>NLM ISO Abbreviation: </i>BMC Cancer <i>Subsets: </i>MEDLINE
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              Text: 2025 Oct 06
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