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Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.

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Title: Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.
Authors: Kim D; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. daeeun.kim@unc.edu.; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. daeeun.kim@unc.edu., Highland HM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Brownsville, TX, USA., Smit RAJ; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Hysong MR; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Buchanan VL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Brownsville, TX, USA., Young KL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Brownsville, TX, USA., Zhao C; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA., Spracklen CN; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Guo B; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Darst BF; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Cai Y; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Wang Z; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lundin J; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA., Manson JE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Marouli E; Barts and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK., Lange L; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lange E; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Gignoux CR; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Haiman CA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA., Rich SS; Center for Public Health Genomics, University of Virginia Charlottesville, Charlottesville, VA, USA., Buyske S; Department of Genetics, Rutgers University, Piscataway, NJ, USA., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Avery CL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gordon-Larsen P; Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Raffield LM; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Kari.E.North@uth.tmc.edu.; Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Brownsville, TX, USA. Kari.E.North@uth.tmc.edu.; Border Health Research Center, UTHealth Houston School of Public Health, 780 Ringgold Road, Brownsville, TX, 78520‑4979, USA. Kari.E.North@uth.tmc.edu.; Department of Internal Medicine, McGovern Medical School, UTHealth Houston School of Public Health, 780 Ringgold Road, Brownsville, TX, 78520‑4979, USA. Kari.E.North@uth.tmc.edu.
Source: Genome medicine [Genome Med] 2025 Oct 06; Vol. 17 (1), pp. 113. Date of Electronic Publication: 2025 Oct 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.
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  Data: <searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. daeeun.kim@unc.edu.; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. daeeun.kim@unc.edu.<br /><searchLink fieldCode="AU" term="%22Highland+HM%22">Highland HM</searchLink>; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Brownsville, TX, USA.<br /><searchLink fieldCode="AU" term="%22Smit+RAJ%22">Smit RAJ</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hysong+MR%22">Hysong MR</searchLink>; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Buchanan+VL%22">Buchanan VL</searchLink>; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Brownsville, TX, USA.<br /><searchLink fieldCode="AU" term="%22Young+KL%22">Young KL</searchLink>; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Brownsville, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+C%22">Zhao C</searchLink>; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.<br /><searchLink fieldCode="AU" term="%22Spracklen+CN%22">Spracklen CN</searchLink>; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kilpeläinen+TO%22">Kilpeläinen TO</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Guo+B%22">Guo B</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Darst+BF%22">Darst BF</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lundin+J%22">Lundin J</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Berndt+SI%22">Berndt SI</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Manson+JE%22">Manson JE</searchLink>; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Marouli+E%22">Marouli E</searchLink>; Barts and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lange+L%22">Lange L</searchLink>; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Lange+E%22">Lange E</searchLink>; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Fornage+M%22">Fornage M</searchLink>; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gignoux+CR%22">Gignoux CR</searchLink>; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Haiman+CA%22">Haiman CA</searchLink>; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Center for Public Health Genomics, University of Virginia Charlottesville, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Buyske+S%22">Buyske S</searchLink>; Department of Genetics, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kooperberg+C%22">Kooperberg C</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Peters+U%22">Peters U</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Avery+CL%22">Avery CL</searchLink>; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Gordon-Larsen+P%22">Gordon-Larsen P</searchLink>; Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Graff+M%22">Graff M</searchLink>; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Raffield+LM%22">Raffield LM</searchLink>; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22North+KE%22">North KE</searchLink>; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Kari.E.North@uth.tmc.edu.; Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Brownsville, TX, USA. Kari.E.North@uth.tmc.edu.; Border Health Research Center, UTHealth Houston School of Public Health, 780 Ringgold Road, Brownsville, TX, 78520‑4979, USA. Kari.E.North@uth.tmc.edu.; Department of Internal Medicine, McGovern Medical School, UTHealth Houston School of Public Health, 780 Ringgold Road, Brownsville, TX, 78520‑4979, USA. Kari.E.North@uth.tmc.edu.
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