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Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.

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Title: Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.
Authors: Jiménez-Vacas JM; The Institute of Cancer Research, London, UK., Westaby D; The Institute of Cancer Research, London, UK.; The Royal Marsden Hospital, London, UK., Figueiredo I; The Institute of Cancer Research, London, UK., De Haven Brandon A; The Institute of Cancer Research, London, UK., Padilha A; The Institute of Cancer Research, London, UK., Yuan W; The Institute of Cancer Research, London, UK., Seed G; The Institute of Cancer Research, London, UK., Bogdan D; The Institute of Cancer Research, London, UK., Gurel B; The Institute of Cancer Research, London, UK., Bertan C; The Institute of Cancer Research, London, UK., Miranda S; The Institute of Cancer Research, London, UK., Lambros M; The Institute of Cancer Research, London, UK., Montero-Hidalgo AJ; The Institute of Cancer Research, London, UK.; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Department of Cell Biology, Physiology, and Immunology, University of Cordoba; Reina Sofia University Hospital; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Cordoba, Spain., Coleman I; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA, USA., Yu IPL; Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada., Buroni L; The Institute of Cancer Research, London, UK., Zeng W; The Institute of Cancer Research, London, UK., Neeb AJ; The Institute of Cancer Research, London, UK., Welti J; The Institute of Cancer Research, London, UK., Rekowski J; The Institute of Cancer Research, London, UK., Paravati R; The Institute of Cancer Research, London, UK., Gabel F; The Institute of Cancer Research, London, UK., Pandell N; The Institute of Cancer Research, London, UK., Ferreira A; The Institute of Cancer Research, London, UK., Crespo M; The Institute of Cancer Research, London, UK., Riisnaes R; The Institute of Cancer Research, London, UK., Das S; The Institute of Cancer Research, London, UK., Taylor J; The Institute of Cancer Research, London, UK., Waldron N; The Institute of Cancer Research, London, UK., Hobern E; The Institute of Cancer Research, London, UK., Valenti M; The Institute of Cancer Research, London, UK., Ning J; The Institute of Cancer Research, London, UK., Bernett I; The Institute of Cancer Research, London, UK., Liodaki K; The Institute of Cancer Research, London, UK., Persse T; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA, USA., Galipeau P; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA, USA., Wilkinson S; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Trostel SY; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Karzai F; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Chau CH; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Beatson EL; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Zhang X; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institute of Health, Rockville, MD, USA., Klumpp-Thomas C; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institute of Health, Rockville, MD, USA., Varkaris A; Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA., Luque RM; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Department of Cell Biology, Physiology, and Immunology, University of Cordoba; Reina Sofia University Hospital; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Cordoba, Spain., Swain A; The Institute of Cancer Research, London, UK., Raynaud F; The Institute of Cancer Research, London, UK., Lack NA; Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Pharmacology, School of Medicine, Koc University, Istanbul, Turkey., Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institute of Health, Rockville, MD, USA.; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Ha G; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA, USA., Figg WD; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Bezzi M; The Institute of Cancer Research, London, UK., Sowalsky AG; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Nelson PS; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA, USA., Carreira S; The Institute of Cancer Research, London, UK., Balk SP; Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA., de Bono JS; The Institute of Cancer Research, London, UK. johann.de-bono@icr.ac.uk.; The Royal Marsden Hospital, London, UK. johann.de-bono@icr.ac.uk., Sharp A; The Institute of Cancer Research, London, UK. adam.sharp@icr.ac.uk.; The Royal Marsden Hospital, London, UK. adam.sharp@icr.ac.uk.
Source: Nature communications [Nat Commun] 2025 Oct 08; Vol. 16 (1), pp. 8806. Date of Electronic Publication: 2025 Oct 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.
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