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Intrathecal STAT3 inhibitor Bt354 ameliorates chronic constriction injury-induced nociceptive sensitization by modulating neuroinflammation.

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Title: Intrathecal STAT3 inhibitor Bt354 ameliorates chronic constriction injury-induced nociceptive sensitization by modulating neuroinflammation.
Authors: Cheng HJ; Division of Pain Management, Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, 112201, Taiwan., Chen NF; Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung, 80284, Taiwan; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, 804201, Taiwan., Tang YC; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan., Shih PC; Institute of Biopharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Chen WF; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan; Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833401, Taiwan., Chiu YJ; National Museum of Marine Biology and Aquarium, Pingtung, 94450, Taiwan., Sung CS; Division of Pain Management, Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, 112201, Taiwan; School of Medicine, National Yang-Ming Chiao Tung University, Taipei, 112304, Taiwan. Electronic address: cssung@vghtpe.gov.tw., Wen ZH; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan; Institute of Biopharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung, 94450, Taiwan. Electronic address: wzh@mail.nsysu.edu.tw.
Source: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2025 Oct; Vol. 22 (6), pp. e00763. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics Country of Publication: United States NLM ID: 101290381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7479 (Electronic) Linking ISSN: 18787479 NLM ISO Abbreviation: Neurotherapeutics Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intrathecal STAT3 inhibitor Bt354 ameliorates chronic constriction injury-induced nociceptive sensitization by modulating neuroinflammation.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+HJ%22">Cheng HJ</searchLink>; Division of Pain Management, Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, 112201, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+NF%22">Chen NF</searchLink>; Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung, 80284, Taiwan; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, 804201, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tang+YC%22">Tang YC</searchLink>; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shih+PC%22">Shih PC</searchLink>; Institute of Biopharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+WF%22">Chen WF</searchLink>; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan; Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833401, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+YJ%22">Chiu YJ</searchLink>; National Museum of Marine Biology and Aquarium, Pingtung, 94450, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sung+CS%22">Sung CS</searchLink>; Division of Pain Management, Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, 112201, Taiwan; School of Medicine, National Yang-Ming Chiao Tung University, Taipei, 112304, Taiwan. Electronic address: cssung@vghtpe.gov.tw.<br /><searchLink fieldCode="AU" term="%22Wen+ZH%22">Wen ZH</searchLink>; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan; Institute of Biopharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung, 94450, Taiwan. Electronic address: wzh@mail.nsysu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101290381%22">Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics</searchLink> [Neurotherapeutics] 2025 Oct; Vol. 22 (6), pp. e00763. <i>Date of Electronic Publication: </i>2025 Oct 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Experimental+NeuroTherapeutics%22">Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101290381 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-7479 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218787479%22">18787479 </searchLink><i>NLM ISO Abbreviation: </i>Neurotherapeutics <i>Subsets: </i>MEDLINE
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              Text: 2025 Oct
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