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Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis.

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Title: Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis.
Authors: Park B; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Nicaise AM; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: an574@cam.ac.uk., Tsitsipatis D; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Pirvan L; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Zucha D; Laboratory of Glial Biology and Omics Technologies, Institute of Biotechnology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic; Department of Informatics and Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, 16000 Prague , Czech Republic., Munteanu A; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Faculty of Computer Science, Alexandru Ioan University, Iasi, Romania., Prasad P; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK., De Novales MLL; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Bulgaru C; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Kollyfas R; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Whitten J; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Willis CM; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK., Culig L; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Llewellyn J; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Ionescu RB; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK., Mekdad M; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK., Simões-Abade MBC; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK., Krzak G; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK., Fan J; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., De S; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Ellis MO; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK; UK Dementia Research Institute at University of Cambridge, Cambridge, UK., Cubero MS; Institute of Molecular Biology, Department of Genomics, Stem Cell Biology and Regenerative Medicine & CMBI, Leopold-Franzens-University Innsbruck, Innsbruck, Austria., Spathopoulou A; Institute of Molecular Biology, Department of Genomics, Stem Cell Biology and Regenerative Medicine & CMBI, Leopold-Franzens-University Innsbruck, Innsbruck, Austria., Peruzzotti-Jametti L; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK; Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK., Leonardi T; Center for Genomic Science of IIT@SEMM, Instituto Italiano di Tecnologia (IIT), 20139 Milan, Italy., Balmus G; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK; UK Dementia Research Institute at University of Cambridge, Cambridge, UK; Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania., Edenhofer F; Institute of Molecular Biology, Department of Genomics, Stem Cell Biology and Regenerative Medicine & CMBI, Leopold-Franzens-University Innsbruck, Innsbruck, Austria., Gorospe M; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Valihrach L; Laboratory of Glial Biology and Omics Technologies, Institute of Biotechnology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic., Mohorianu I; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK. Electronic address: iim22@cam.ac.uk., Pluchino S; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: spp24@cam.ac.uk., Beerman I; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Electronic address: isabel.beerman@nih.gov.
Source: Neuron [Neuron] 2025 Dec 17; Vol. 113 (24), pp. 4158-4177.e10. Date of Electronic Publication: 2025 Oct 10.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
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  Data: Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Park+B%22">Park B</searchLink>; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Nicaise+AM%22">Nicaise AM</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: an574@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Tsitsipatis+D%22">Tsitsipatis D</searchLink>; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Pirvan+L%22">Pirvan L</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Zucha+D%22">Zucha D</searchLink>; Laboratory of Glial Biology and Omics Technologies, Institute of Biotechnology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic; Department of Informatics and Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, 16000 Prague , Czech Republic.<br /><searchLink fieldCode="AU" term="%22Munteanu+A%22">Munteanu A</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Faculty of Computer Science, Alexandru Ioan University, Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Prasad+P%22">Prasad P</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK.<br /><searchLink fieldCode="AU" term="%22De+Novales+MLL%22">De Novales MLL</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Bulgaru+C%22">Bulgaru C</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Kollyfas+R%22">Kollyfas R</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Whitten+J%22">Whitten J</searchLink>; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Willis+CM%22">Willis CM</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK.<br /><searchLink fieldCode="AU" term="%22Culig+L%22">Culig L</searchLink>; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Llewellyn+J%22">Llewellyn J</searchLink>; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Ionescu+RB%22">Ionescu RB</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK.<br /><searchLink fieldCode="AU" term="%22Mekdad+M%22">Mekdad M</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK.<br /><searchLink fieldCode="AU" term="%22Simões-Abade+MBC%22">Simões-Abade MBC</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK.<br /><searchLink fieldCode="AU" term="%22Krzak+G%22">Krzak G</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK.<br /><searchLink fieldCode="AU" term="%22Fan+J%22">Fan J</searchLink>; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22De+S%22">De S</searchLink>; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Ellis+MO%22">Ellis MO</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK; UK Dementia Research Institute at University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cubero+MS%22">Cubero MS</searchLink>; Institute of Molecular Biology, Department of Genomics, Stem Cell Biology and Regenerative Medicine & CMBI, Leopold-Franzens-University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Spathopoulou+A%22">Spathopoulou A</searchLink>; Institute of Molecular Biology, Department of Genomics, Stem Cell Biology and Regenerative Medicine & CMBI, Leopold-Franzens-University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Peruzzotti-Jametti+L%22">Peruzzotti-Jametti L</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK; Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.<br /><searchLink fieldCode="AU" term="%22Leonardi+T%22">Leonardi T</searchLink>; Center for Genomic Science of IIT@SEMM, Instituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Balmus+G%22">Balmus G</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK; UK Dementia Research Institute at University of Cambridge, Cambridge, UK; Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania.<br /><searchLink fieldCode="AU" term="%22Edenhofer+F%22">Edenhofer F</searchLink>; Institute of Molecular Biology, Department of Genomics, Stem Cell Biology and Regenerative Medicine & CMBI, Leopold-Franzens-University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Gorospe+M%22">Gorospe M</searchLink>; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Valihrach+L%22">Valihrach L</searchLink>; Laboratory of Glial Biology and Omics Technologies, Institute of Biotechnology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Mohorianu+I%22">Mohorianu I</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK. Electronic address: iim22@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Pluchino+S%22">Pluchino S</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: spp24@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Beerman+I%22">Beerman I</searchLink>; Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Electronic address: isabel.beerman@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%228809320%22">Neuron</searchLink> [Neuron] 2025 Dec 17; Vol. 113 (24), pp. 4158-4177.e10. <i>Date of Electronic Publication: </i>2025 Oct 10.
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