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A fluconazole population pharmacokinetics study to improve target attainment in critically ill patients.

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Title: A fluconazole population pharmacokinetics study to improve target attainment in critically ill patients.
Authors: Vuong ML; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium., Elkayal O; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium.; Novo Nordisk, Copenhagen, Denmark., Van Daele R; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium.; Pharmacy Department, University Hospitals Leuven, Leuven, Belgium.; Gilead Sciences, Diegem, Belgium., Alffenaar JC; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.; Pharmacy Department, Westmead Hospital, Sydney, Australia.; Institute for Infectious Diseases (Sydney ID), The University of Sydney, Sydney, Australia., Stocker SL; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.; Institute for Infectious Diseases (Sydney ID), The University of Sydney, Sydney, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.; Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital, Sydney, Australia., Roberts JA; University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Australia.; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France., Debaveye Y; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.; Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium., Wauters J; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium., Mertens B; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium.; Pharmacy Department, University Hospitals Leuven, Leuven, Belgium.; AZ Turnhout, Antwerp, Belgium., Boonstra JM; University Medical Centre Groningen, Department of Clinical Pharmacy and Pharmacology, University of Groningen, Groningen, The Netherlands.; ICON plc, Groningen, The Netherlands., Sandaradura I; Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, Australia.; Faculty of Medicine and Health, Westmead Clinical School, The University of Sydney, Sydney, Australia.; Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Sydney, Australia., Marriott DJE; St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, NSW, Australia.; Clinical Microbiology and Infectious Diseases Department, St. Vincent's Hospital, Sydney, NSW, Australia., Brüggemann RJ; Department of Pharmacy, Radboud university medical centre, Radboud Institute for Medical Innovations, Nijmegen, The Netherlands.; Radboudumc/CWZ Centre of Expertise in Mycology, Nijmegen, The Netherlands., Schouten JA; Department of Intensive Care, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands., Bergner R; Division of Rheumatology and Nephrology, Department of Medicine A, Ludwigshafen Medical Centre, Ludwigshafen, Germany., Buijk S; Department of Surgery, IJsseland Hospital, Capelle aan den Ijssel, The Netherlands., Spriet I; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium.; Pharmacy Department, University Hospitals Leuven, Leuven, Belgium., Dreesen E; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium. erwin.dreesen@kuleuven.be.
Source: Infection [Infection] 2026 Feb; Vol. 54 (1), pp. 299-313. Date of Electronic Publication: 2025 Oct 14.
Publication Type: Journal Article
Journal Info: Publisher: Springer Heidelberg Country of Publication: Germany NLM ID: 0365307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0973 (Electronic) Linking ISSN: 03008126 NLM ISO Abbreviation: Infection Subsets: MEDLINE
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  Data: A fluconazole population pharmacokinetics study to improve target attainment in critically ill patients.
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  Data: <searchLink fieldCode="AU" term="%22Vuong+ML%22">Vuong ML</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Elkayal+O%22">Elkayal O</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium.; Novo Nordisk, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Van+Daele+R%22">Van Daele R</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium.; Pharmacy Department, University Hospitals Leuven, Leuven, Belgium.; Gilead Sciences, Diegem, Belgium.<br /><searchLink fieldCode="AU" term="%22Alffenaar+JC%22">Alffenaar JC</searchLink>; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.; Pharmacy Department, Westmead Hospital, Sydney, Australia.; Institute for Infectious Diseases (Sydney ID), The University of Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Stocker+SL%22">Stocker SL</searchLink>; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.; Institute for Infectious Diseases (Sydney ID), The University of Sydney, Sydney, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.; Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Roberts+JA%22">Roberts JA</searchLink>; University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Australia.; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.<br /><searchLink fieldCode="AU" term="%22Debaveye+Y%22">Debaveye Y</searchLink>; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.; Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Wauters+J%22">Wauters J</searchLink>; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Mertens+B%22">Mertens B</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium.; Pharmacy Department, University Hospitals Leuven, Leuven, Belgium.; AZ Turnhout, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Boonstra+JM%22">Boonstra JM</searchLink>; University Medical Centre Groningen, Department of Clinical Pharmacy and Pharmacology, University of Groningen, Groningen, The Netherlands.; ICON plc, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sandaradura+I%22">Sandaradura I</searchLink>; Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, Australia.; Faculty of Medicine and Health, Westmead Clinical School, The University of Sydney, Sydney, Australia.; Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Marriott+DJE%22">Marriott DJE</searchLink>; St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, NSW, Australia.; Clinical Microbiology and Infectious Diseases Department, St. Vincent's Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Brüggemann+RJ%22">Brüggemann RJ</searchLink>; Department of Pharmacy, Radboud university medical centre, Radboud Institute for Medical Innovations, Nijmegen, The Netherlands.; Radboudumc/CWZ Centre of Expertise in Mycology, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schouten+JA%22">Schouten JA</searchLink>; Department of Intensive Care, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bergner+R%22">Bergner R</searchLink>; Division of Rheumatology and Nephrology, Department of Medicine A, Ludwigshafen Medical Centre, Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Buijk+S%22">Buijk S</searchLink>; Department of Surgery, IJsseland Hospital, Capelle aan den Ijssel, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Spriet+I%22">Spriet I</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium.; Pharmacy Department, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Dreesen+E%22">Dreesen E</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49 box 521, Leuven, 3000, Belgium. erwin.dreesen@kuleuven.be.
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  Data: <searchLink fieldCode="JN" term="%220365307%22">Infection</searchLink> [Infection] 2026 Feb; Vol. 54 (1), pp. 299-313. <i>Date of Electronic Publication: </i>2025 Oct 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Heidelberg%22">Springer Heidelberg </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0365307 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1439-0973 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203008126%22">03008126 </searchLink><i>NLM ISO Abbreviation: </i>Infection <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb
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